Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.0254 | 0.1079 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0254 | 0.1079 | 0.0517 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0254 | 0.1079 | 0.0517 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.1079 | 0.1079 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0254 | 0.1079 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0254 | 0.1079 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0254 | 0.1079 | 0.1079 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0254 | 0.1079 | 0.1079 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.1165 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0.1079 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.1165 | 1 | 1 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Giardia lamblia | Serine peptidase, putative | 0.0254 | 0.1079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 1 | 1 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1165 | 1 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0254 | 0.1079 | 0.0517 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.1165 | 1 | 1 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0254 | 0.1079 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.0254 | 0.1079 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0254 | 0.1079 | 0.5 |
Onchocerca volvulus | 0.0254 | 0.1079 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.