Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0032 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0102 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 1 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Plasmodium falciparum | hexose transporter | 0.0102 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0032 | 0.1693 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0102 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 1 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1693 | 1 |
Trypanosoma brucei | glucose transporter 1E | 0.0032 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Leishmania major | glucose transporter, lmgt2 | 0.0032 | 0.1693 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1693 | 1 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Plasmodium vivax | hexose transporter | 0.0102 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0102 | 1 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 1 | 0.5 |
Leishmania major | glucose transporter, lmgt1 | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter 2A | 0.0032 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0032 | 0.1693 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0032 | 0.1693 | 0.5 |
Trypanosoma cruzi | hexose transporter | 0.0032 | 0.1693 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 26.97 um | PUBCHEM_BIOASSAY: Dose response biochemical screening assay for inhibitors of c-Jun N-Terminal Kinase 3 (JNK3). (Class of assay: confirmatory) [Related pubchem assays: 746 ] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.