Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0811 | 0.2791 | 0.2791 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.2413 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0191 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0191 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0191 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0811 | 0.2791 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0811 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0191 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0811 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0191 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0811 | 0.2791 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0191 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.2413 | 1 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0811 | 0.2791 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0811 | 0.2791 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0191 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0191 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0191 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0191 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.2413 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0191 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.2413 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0811 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.062 | 0.193 | 0.193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.193 | 0.193 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0191 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0191 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0191 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0191 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0811 | 0.2791 | 0.2791 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.2413 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0811 | 0.2791 | 0.2791 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.5733 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.