Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | CREB binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2137 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0317 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0037 | 0 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0097 | 0.2137 | 0.2137 |
Loa Loa (eye worm) | CBP-B | 0.0085 | 0.172 | 0.8046 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0097 | 0.2137 | 0.2137 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0097 | 0.2137 | 0.6993 |
Echinococcus granulosus | CREB binding protein | 0.0122 | 0.3056 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0097 | 0.2137 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0097 | 0.2137 | 0.6993 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0122 | 0.3056 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2137 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0097 | 0.2137 | 0.6993 |
Echinococcus granulosus | laminin | 0.0097 | 0.2137 | 0.6993 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0097 | 0.2137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2137 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0097 | 0.2137 | 0.6993 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2137 | 1 |
Echinococcus multilocularis | laminin | 0.0097 | 0.2137 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0097 | 0.2137 | 0.6993 |
Echinococcus multilocularis | fibrillin 1 | 0.0097 | 0.2137 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0084 | 0.1682 | 0.7868 |
Echinococcus granulosus | CREB binding protein | 0.0075 | 0.138 | 0.4514 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0097 | 0.2137 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0097 | 0.2137 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0097 | 0.2137 | 1 |
Brugia malayi | TAZ zinc finger family protein | 0.0122 | 0.3056 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0122 | 0.3056 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0097 | 0.2137 | 0.6993 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0735 | 0.344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Cell signaling CRE-BLA (Fsk stim). (Class of assay: confirmatory) [Related pubchem assays: 662 ] | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Cell signaling CRE-BLA (Fsk stim) - HEK293 CREB Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 662 ] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: Cell Viability - CRE-beta lactamase CHO cell - 40 hr assay. (Class of assay: confirmatory) [Related pubchem assays: 662 ] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.