Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | oxidoreductase | 0.0047 | 0.0026 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0691 | 1 | 1 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.0047 | 0.0026 | 0.0003 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0047 | 0.0026 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0047 | 0.0026 | 1 |
Onchocerca volvulus | 0.0047 | 0.0026 | 0.5 | |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0047 | 0.0026 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0047 | 0.0026 | 0.0163 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0047 | 0.0026 | 0.0003 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0047 | 0.0026 | 0.0003 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0691 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0047 | 0.0026 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0047 | 0.0026 | 0.0003 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0047 | 0.0026 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.0024 | 0.9016 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0047 | 0.0026 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0691 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0047 | 0.0026 | 0.0003 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0047 | 0.0026 | 0.0003 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.0047 | 0.0026 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0026 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.0948 | 0.0927 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.1132 | 0.1111 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0047 | 0.0026 | 0.0003 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.0047 | 0.0026 | 0.0003 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0047 | 0.0026 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.0948 | 0.0927 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.0948 | 0.0927 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.1132 | 0.1111 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0047 | 0.0026 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.0024 | 0.9016 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0047 | 0.0026 | 0.0003 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0047 | 0.0026 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.0948 | 0.0925 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0691 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0047 | 0.0026 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0691 | 1 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0691 | 1 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0047 | 0.0026 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0691 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.1132 | 0.1109 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.0024 | 0.9016 |
Brugia malayi | glutathione reductase | 0.0047 | 0.0024 | 0.9016 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.0047 | 0.0026 | 0.0003 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0047 | 0.0026 | 1 |
Leishmania major | oxidoreductase-like protein | 0.0047 | 0.0026 | 1 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.0047 | 0.0026 | 0.0003 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0691 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.0024 | 0.9016 |
Leishmania major | pteridine reductase 1 | 0.0047 | 0.0026 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.0948 | 0.0927 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0047 | 0.0026 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.0948 | 0.0927 |
Schistosoma mansoni | dihydropteridine reductase | 0.0047 | 0.0026 | 0.0163 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.0024 | 0.9016 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.1132 | 0.1111 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0047 | 0.0026 | 0.0003 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0047 | 0.0026 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.0948 | 0.0927 |
Trypanosoma brucei | pteridine reductase 1 | 0.0047 | 0.0026 | 1 |
Onchocerca volvulus | 0.0047 | 0.0026 | 0.5 | |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.0047 | 0.0026 | 0.0003 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0047 | 0.0026 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 30 uM | Ability to inhibit platelet aggregation of human platelet-rich plasma (PRP) induced by 800 uM of AA-IPA (arachidonic acid) | ChEMBL. | 2391688 |
IC50 (functional) | = 30 uM | Ability to inhibit platelet aggregation of human platelet-rich plasma (PRP) induced by 800 uM of AA-IPA (arachidonic acid) | ChEMBL. | 2391688 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.