Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1352 | 0.1352 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.4365 | 0.4365 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.3866 | 0.3866 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1352 | 0.1352 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0254 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.1352 | 0.1352 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1352 | 0.1352 |
Echinococcus granulosus | tar DNA binding protein | 0.0254 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.1352 | 0.1352 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1352 | 0.1352 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.4365 | 0.4365 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.1352 | 0.1352 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.016 | 0.6032 | 0.6032 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 0.6032 | 0.6032 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 0.6032 | 0.6032 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.1352 | 0.1352 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.6032 | 0.6032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0254 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0254 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0254 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0254 | 1 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1352 | 0.1352 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.1352 | 0.1352 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.3866 | 0.3866 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.011 | 0.3866 | 0.3866 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.1352 | 0.1352 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.1352 | 0.1352 |
Schistosoma mansoni | tar DNA-binding protein | 0.0254 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.1352 | 0.1352 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.4365 | 0.4365 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0254 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.1352 | 0.1352 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.