Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase II | 0.1103 | 0.3426 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1416 | 1 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1351 | 0.8639 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1351 | 0.8639 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.112 | 0.3773 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1351 | 0.8639 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1103 | 0.3426 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1103 | 0.3426 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1103 | 0.3426 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1103 | 0.3426 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.094 | 0 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1103 | 0.3426 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1103 | 0.3426 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1416 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1351 | 0.8639 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.