Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0697 | 0.6086 | 0.9264 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0697 | 0.6086 | 0.5 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.1036 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0736 | 0.6539 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0697 | 0.6086 | 0.9264 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0736 | 0.6539 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0697 | 0.6086 | 0.9264 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0736 | 0.6539 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0697 | 0.6086 | 0.5 |
Trypanosoma brucei | trans-sialidase | 0.0171 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.8048 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.