Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1898 | 0.1898 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0.0934 | 0.1043 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1898 | 0.1898 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0036 | 0.0934 | 0.0934 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0036 | 0.0934 | 0.0934 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.2359 | 0.359 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0036 | 0.0934 | 0.0934 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0123 | 0.5781 | 0.6451 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1898 | 0.1898 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0199 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0.0934 | 0.1043 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0966 | 0.1078 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0036 | 0.0934 | 0.0934 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0199 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0036 | 0.0934 | 0.1043 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 1 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0199 | 1 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0036 | 0.0934 | 0.1043 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0036 | 0.0934 | 0.1043 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.8961 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0199 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0036 | 0.0934 | 0.1043 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0442 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0036 | 0.0934 | 0.0934 |
Echinococcus multilocularis | geminin | 0.0181 | 0.8961 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0123 | 0.5781 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0036 | 0.0934 | 0.0934 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0138 | 0.6595 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0123 | 0.5781 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0036 | 0.0934 | 0.1043 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0036 | 0.0934 | 0.1043 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | steroid hormone receptor | 0.0036 | 0.0934 | 0.0934 |
Leishmania major | hypothetical protein, conserved | 0.0061 | 0.2359 | 0.359 |
Echinococcus granulosus | FTZ F1 alpha | 0.0036 | 0.0934 | 0.1043 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0036 | 0.0934 | 0.0934 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0036 | 0.0934 | 0.1043 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0.0934 | 0.1043 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0123 | 0.5781 | 0.6451 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0036 | 0.0934 | 0.1043 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0036 | 0.0934 | 0.1043 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0966 | 0.0966 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0123 | 0.5781 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0199 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0036 | 0.0934 | 0.1043 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0123 | 0.5781 | 0.6451 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0.0934 | 0.1043 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0442 | 0.0442 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0036 | 0.0934 | 0.0934 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0036 | 0.0934 | 0.1043 |
Onchocerca volvulus | 0.0199 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0036 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0123 | 0.5781 | 0.5781 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0123 | 0.5781 | 0.6451 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0036 | 0.0934 | 0.1043 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0036 | 0.0934 | 0.1043 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1898 | 0.1898 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0442 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0036 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0966 | 0.0966 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0036 | 0.0934 | 0.0934 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0123 | 0.5781 | 0.6451 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0123 | 0.5781 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0036 | 0.0934 | 0.0934 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0123 | 0.5781 | 0.6451 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0.0934 | 0.1043 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0442 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0036 | 0.0934 | 0.0934 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0199 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.8961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | ecdysteroid receptor | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | nuclear receptor NHR-88 | 0.0036 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0036 | 0.0934 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0442 | 0.0442 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0061 | 0.2359 | 0.359 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0.0934 | 0.1043 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | P38 map kinase family protein 2 | 0.0123 | 0.5781 | 0.5781 |
Echinococcus granulosus | geminin | 0.0181 | 0.8961 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0036 | 0.0934 | 0.0934 |
Schistosoma mansoni | coup transcription factor | 0.0036 | 0.0934 | 0.1043 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0199 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0036 | 0.0934 | 0.0934 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0036 | 0.0934 | 0.1043 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0061 | 0.2359 | 0.359 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0036 | 0.0934 | 0.1043 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0442 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.3831 | 0.3831 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0036 | 0.0934 | 0.0934 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0036 | 0.0934 | 0.1043 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0036 | 0.0934 | 0.0934 |
Brugia malayi | nuclear hormone receptor | 0.0036 | 0.0934 | 0.0934 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0.0934 | 0.1043 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0036 | 0.0934 | 0.0934 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | = 112.2018 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.