Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0368 | 0.1202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1202 | 1 |
Onchocerca volvulus | 0.0368 | 0.1202 | 1 | |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0368 | 0.1202 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0368 | 0.1202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1202 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0368 | 0.1202 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0368 | 0.1202 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0368 | 0.1202 | 0.1387 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0368 | 0.1202 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0368 | 0.1202 | 0.1202 |
Schistosoma mansoni | amine oxidase | 0.0368 | 0.1202 | 0.1202 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0368 | 0.1202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1202 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0368 | 0.1202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1202 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1202 | 1 |
Brugia malayi | hypothetical protein | 0.0368 | 0.1202 | 1 |
Echinococcus multilocularis | 0.0368 | 0.1202 | 0.1202 | |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.243 | 0.8667 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2798 | 1 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2798 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0368 | 0.1202 | 0.1387 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.0779 | 0.6483 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2798 | 1 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0368 | 0.1202 | 0.1202 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0368 | 0.1202 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0368 | 0.1202 | 0.1202 |
Brugia malayi | SWIRM domain containing protein | 0.0368 | 0.1202 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0368 | 0.1202 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0368 | 0.1202 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2798 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.0779 | 0.6483 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.243 | 0.8667 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.0905 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0368 | 0.1202 | 0.5 |
Onchocerca volvulus | 0.0286 | 0.0905 | 0.7528 | |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1202 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0368 | 0.1202 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3981 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 22.3872 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.