Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.9936 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0221 | 0.9859 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0221 | 0.9859 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.9936 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.011 | 0.3375 | 0.3099 |
Brugia malayi | thymidylate synthase | 0.011 | 0.3375 | 0.3423 |
Brugia malayi | Dihydrofolate reductase | 0.0221 | 0.9859 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0462 | 0.0469 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0221 | 0.9859 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0221 | 0.9859 | 0.9788 |
Echinococcus granulosus | dihydrofolate reductase | 0.0221 | 0.9859 | 0.9788 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0221 | 0.9859 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.8303 | 0.76 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0221 | 0.9859 | 1 |
Onchocerca volvulus | 0.011 | 0.3375 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.9936 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0221 | 0.9859 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.011 | 0.3375 | 0.3423 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0221 | 0.9859 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.9936 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0222 | 0.9936 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0222 | 0.9936 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0462 | 0.0469 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | kinesin family 1 | 0.0223 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.