TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.477 | Formula: C19H24FN3OS
H donors: 1 H acceptors: 2 LogP: 3.87 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)c1nc(sc1CCC2)NCCCCC(=O)N(C)C
InChi: 1S/C19H24FN3OS/c1-23(2)17(24)8-3-4-11-21-19-22-18-15-12-14(20)10-9-13(15)6-5-7-16(18)25-19/h9-10,12H,3-8,11H2,1-2H3,(H,21,22)
InChiKey: JKEBCVSDYKYACQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptide Y receptor Y5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	aldo-keto reductase	0.0064	0.1158	0.1119
Onchocerca volvulus		0.0064	0.1158	0.6413
Brugia malayi	ShTK domain containing protein	0.009	0.1781	0.2803
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1488	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0171	0.1141
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.2494	0.3974
Loa Loa (eye worm)	oxidoreductase	0.0064	0.1158	0.1824
Giardia lamblia	Aldose reductase	0.0064	0.1158	0.5
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0834	0.2389
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0702	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0171	0.0236
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0064	0.1158	0.1603
Trichomonas vaginalis	glutaminase, putative	0.0272	0.6242	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0064	0.1158	0.1798
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Onchocerca volvulus		0.0064	0.1158	0.6413
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0631	0.0845
Leishmania major	aldo-keto reductase-like protein	0.0064	0.1158	0.1603
Echinococcus granulosus	geminin	0.0168	0.3704	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0702	0.18
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.08	0.1248
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Loa Loa (eye worm)	hypothetical protein	0.009	0.1781	0.2826
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0064	0.1158	0.1798
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0702	0.18
Echinococcus multilocularis	aldo keto reductase	0.0064	0.1158	0.3044
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0243	0.1501
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Schistosoma mansoni	hypothetical protein	0.0168	0.3704	0.3676
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Brugia malayi	Probable ClpP-like protease	0.0078	0.1488	0.2331
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.009	0.1781	0.2803
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0171	0.0236
Trichomonas vaginalis	aldo/keto reductase, putative	0.0064	0.1158	0.1798
Echinococcus multilocularis	geminin	0.0168	0.3704	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0143	0.3095	0.4388
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0064	0.1158	0.1603
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Echinococcus granulosus	aldo keto reductase	0.0064	0.1158	0.3044
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0171	0.0183
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0702	0.0662
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0702	0.18
Echinococcus granulosus	hypothetical protein	0.0064	0.1158	0.3044
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	0.2355
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0064	0.1158	0.1798
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0417	0.0602
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0171	0.0236
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0702	0.1063
Brugia malayi	Carboxylesterase family protein	0.0066	0.12	0.1866
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Mycobacterium tuberculosis	Probable oxidoreductase	0.0064	0.1158	0.3317
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0171	0.0236
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0631	0.0845
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0064	0.1158	0.1798
Mycobacterium ulcerans	oxidoreductase	0.0064	0.1158	0.1824
Echinococcus multilocularis	aldehyde reductase	0.0046	0.0703	0.1803
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0061	0.1092	0.1691
Onchocerca volvulus		0.009	0.1781	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Schistosoma mansoni	hypothetical protein	0.0168	0.3704	0.3676
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0243	0.1384
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0064	0.1158	0.1798
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0171	0.0236
Brugia malayi	MH2 domain containing protein	0.0119	0.2494	0.3954
Toxoplasma gondii	hypothetical protein	0.0049	0.0784	0.5125
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Echinococcus granulosus	aldehyde reductase	0.0046	0.0703	0.1803
Brugia malayi	Carboxylesterase family protein	0.0066	0.12	0.1866
Echinococcus multilocularis	aldo keto reductase	0.0064	0.1158	0.3044
Brugia malayi	Common central domain of tyrosinase family protein	0.009	0.1781	0.2803
Plasmodium falciparum	aldo-keto reductase, putative	0.0019	0.0044	0.0136
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0171	0.0236
Entamoeba histolytica	aldose reductase, putative	0.0064	0.1158	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Onchocerca volvulus		0.0064	0.1158	0.6413
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.12	0.316
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0171	0.0236
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.1488	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0171	0.0183
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0159	0.3491	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0171	0.0489
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Loa Loa (eye worm)	oxidoreductase	0.0064	0.1158	0.1824
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0171	0.1141
Brugia malayi	glutaminase DH11.1	0.0272	0.6242	1
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0019	0.0044	0.0136
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0702	0.0662
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.1488	0.3947
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0044	0.0032
Echinococcus granulosus	aldo keto reductase	0.0064	0.1158	0.3044
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0064	0.1158	0.1798
Giardia lamblia	Aldose reductase	0.0064	0.1158	0.5
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0834	0.2159
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1158	0.1824
Echinococcus multilocularis	aldo keto reductase	0.0064	0.1158	0.3044
Loa Loa (eye worm)	acetylcholinesterase 1	0.0066	0.12	0.1892
Schistosoma mansoni	hypothetical protein	0.0034	0.0417	0.0375
Loa Loa (eye worm)	ShTK domain-containing protein	0.009	0.1781	0.2826
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1488	0.2355
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0061	0.1092	0.1717
Schistosoma mansoni	tyrosinase precursor	0.0425	1	1
Plasmodium falciparum	aldehyde reductase, putative	0.0019	0.0044	0.0136
Onchocerca volvulus		0.009	0.1781	1
Echinococcus multilocularis	carboxylesterase 5A	0.0066	0.12	0.316
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.009	0.1781	0.2803
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Brugia malayi	Muscleblind-like protein	0.015	0.3253	0.5178
Echinococcus multilocularis	muscleblind protein	0.015	0.3253	0.8768
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0171	0.0236
Echinococcus multilocularis	acetylcholinesterase	0.0066	0.12	0.316
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.1488	1
Echinococcus granulosus	acetylcholinesterase	0.0066	0.12	0.316
Loa Loa (eye worm)	hypothetical protein	0.015	0.3253	0.5193
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.08	0.122
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	1
Loa Loa (eye worm)	hypothetical protein	0.015	0.3253	0.5193
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0171	0.088
Schistosoma mansoni	pol-related	0.0064	0.1158	0.1119
Onchocerca volvulus		0.0064	0.1158	0.6413
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0066	0.12	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0066	0.12	0.1892
Loa Loa (eye worm)	carboxylesterase	0.0066	0.12	0.1892
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0171	0.1141
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	0.2355
Toxoplasma gondii	aldose reductase, putative	0.0064	0.1158	0.7713
Onchocerca volvulus		0.0064	0.1158	0.6413
Mycobacterium ulcerans	glutaminase	0.0272	0.6242	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0702	0.0662
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0064	0.1158	0.3044
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Trypanosoma cruzi	aldo/keto reductase, putative	0.0064	0.1158	0.1603
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.009	0.1781	0.2803
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Echinococcus granulosus	acetylcholinesterase	0.0066	0.12	0.316
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0019	0.0044	0.0032
Onchocerca volvulus		0.0064	0.1158	0.6413
Schistosoma mansoni	hypothetical protein	0.0061	0.1092	0.1053
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0171	0.0183
Plasmodium vivax	aldehyde reductase, putative	0.0019	0.0044	0.0136
Leishmania major	prostaglandin f synthase, putative	0.0064	0.1158	0.1603
Onchocerca volvulus		0.009	0.1781	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Loa Loa (eye worm)	oxidoreductase	0.0064	0.1158	0.1824
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0631	0.0845
Toxoplasma gondii	hypothetical protein	0.0027	0.0243	0.1384
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Mycobacterium tuberculosis	Conserved protein	0.0019	0.0044	0.0125
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0024	0.0068
Onchocerca volvulus		0.009	0.1781	1
Mycobacterium leprae	Conserved hypothetical protein	0.0046	0.0703	0.4568
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0064	0.1158	0.1798
Entamoeba histolytica	aldose reductase, putative	0.0064	0.1158	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	0.5
Echinococcus multilocularis	dnaJ subfamily C 6	0.0061	0.1092	0.2863
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.08	0.122
Loa Loa (eye worm)	hypothetical protein	0.009	0.1781	0.2826
Entamoeba histolytica	aldose reductase, putative	0.0064	0.1158	1
Leishmania major	mitochondrial DNA polymerase beta	0.0303	0.6997	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.3095	0.4388
Loa Loa (eye worm)	ShTK domain-containing protein	0.009	0.1781	0.2826
Loa Loa (eye worm)	tyrosinase 1	0.009	0.1781	0.2826
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.1488	0.3947
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0303	0.6997	1
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.009	0.1781	0.2803
Trichomonas vaginalis	aldo/keto reductase, putative	0.0064	0.1158	0.1798
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.0631	0.0845
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Echinococcus granulosus	carboxylesterase 5A	0.0066	0.12	0.316
Trypanosoma brucei	aldo-keto reductase, putative	0.0064	0.1158	0.1603
Echinococcus multilocularis	aldo keto reductase	0.0064	0.1158	0.3044
Schistosoma mansoni	glutaminase	0.0272	0.6242	0.6225
Loa Loa (eye worm)	oxidoreductase	0.0064	0.1158	0.1824
Mycobacterium ulcerans	hypothetical protein	0.0159	0.3491	0.5576
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0834	0.2389
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0171	0.088
Loa Loa (eye worm)	glutaminase 2	0.0272	0.6242	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0303	0.6997	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0171	0.0236
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0303	0.6997	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.12	0.1892
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0834	0.5471
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0171	0.0205
Schistosoma mansoni	aldo-keto reductase	0.0064	0.1158	0.1119
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0064	0.1158	0.3044
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0171	0.0236
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0171	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0049	0.08	0.1248
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0064	0.1158	0.7713
Trypanosoma brucei	prostaglandin f synthase	0.0064	0.1158	0.1603
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0702	0.18
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0171	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0171	0.0236
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1488	1
Brugia malayi	DnaJ domain containing protein	0.0061	0.1092	0.1691
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0859	0.1172
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.3095	0.4388
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0417	0.0632
Trichomonas vaginalis	aldo-keto reductase, putative	0.0064	0.1158	0.1798
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0171	0.0489
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0243	0.1501
Echinococcus granulosus	aldo keto reductase	0.0064	0.1158	0.3044
Onchocerca volvulus		0.0024	0.0171	0.0732
Loa Loa (eye worm)	glutaminase	0.0272	0.6242	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.2494	0.3974
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0834	0.2159
Echinococcus granulosus	muscleblind protein	0.015	0.3253	0.8768
Echinococcus granulosus	dnaJ subfamily C 6	0.0061	0.1092	0.2863
Trichomonas vaginalis	aldo/keto reductase, putative	0.0064	0.1158	0.1798
Echinococcus multilocularis	muscleblind protein 1	0.015	0.3253	0.8768
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.1488	0.1451
Loa Loa (eye worm)	oxidoreductase	0.0064	0.1158	0.1824
Trypanosoma cruzi	aldo-keto reductase	0.0064	0.1158	0.1603

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 25 nM	In vitro binding affinity of the compound against human neuropeptide Y5 receptor	ChEMBL.	15109631
IC50 (binding)	= 25 nM	In vitro binding affinity of the compound against human neuropeptide Y5 receptor	ChEMBL.	15109631

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 133999