TDR Targets

Basic information

Technical information

TDR Targets ID: 1340073
Name: 3-(4-chlorophenyl)-1-[4-(difluoromethoxy)phen yl]-6,7,8,9-tetrahydro-5H-imidazo[3,2-a]azepi n-4-ium bromide
MW: 469.75 | Formula: C21H20BrClF2N2O
H donors: 0 H acceptors: 0 LogP: 7.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: FC(Oc1ccc(cc1)[n+]1cc(n2c1CCCCC2)c1ccc(cc1)Cl)F.[Br-]
InChi: 1S/C21H20ClF2N2O.BrH/c22-16-7-5-15(6-8-16)19-14-26(20-4-2-1-3-13-25(19)20)17-9-11-18(12-10-17)27-21(23)24;/h5-12,14,21H,1-4,13H2;1H/q+1;/p-1
InChiKey: FTKGWICXVGBKSU-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(4-Chloro-phenyl)-1-(4-difluoromethoxy-phenyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepin-1-ium
MLS001029571
SMR000425034

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	neuropeptide F receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptide s receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.7283	0.4581
Echinococcus granulosus	g protein coupled receptor	0.0026	0.7283	0.4581
Brugia malayi	Dopamine receptor protein 1	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus granulosus	7tm_1 domain containing protein	0.0026	0.7283	0.4581
Schistosoma mansoni	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus multilocularis	dro:myosuppressin receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide receptor A26	0.0026	0.7283	0.4581
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0026	0.7283	0.4581
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.4987	0.6723
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.7283	0.4581
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0026	0.7283	0.4581
Schistosoma mansoni	myosin xvIII	0.0026	0.7283	0.4581
Brugia malayi	Serotonin receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	follicle stimulating hormone receptor	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	amine GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7418	1
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0026	0.7283	0.4581
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.4987	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0026	0.7283	0.9819
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	neuropeptide f receptor 76f	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide s receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	histamine h1 receptor	0.0026	0.7283	0.4581
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.4987	0.4987
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Brugia malayi	G-protein coupled receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0026	0.7283	0.9819
Schistosoma mansoni	biogenic amine receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0026	0.7283	0.4581
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0026	0.7283	0.4581
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0026	0.7283	0.4581
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Brugia malayi	Dopamine receptor protein 2	0.0026	0.7283	0.4581
Schistosoma mansoni	growth hormone secretagogue receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Loa Loa (eye worm)	TYRA-2 protein	0.0026	0.7283	0.9819
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.4987	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	Serotonin receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0026	0.7283	0.4581
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.7283	0.4581
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	1	1
Schistosoma mansoni	amine GPCR	0.0026	0.7283	0.4581
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Entamoeba histolytica	hypothetical protein	0.003	1	1
Giardia lamblia	GTOR	0.0022	0.4987	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	allatostatin A receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus granulosus	orexin receptor type 2	0.0026	0.7283	0.4581
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.5013	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	amine GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	hypothetical protein	0.0026	0.7283	0.4581
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.7283	0.9819
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0026	0.7283	0.4581
Schistosoma mansoni	amine GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	G-protein coupled receptor	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.5013	0.0052
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0026	0.7283	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	biogenic amine receptor	0.0026	0.7283	0.4581
Brugia malayi	RE15519p	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Brugia malayi	Melatonin receptor type 1A	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.7418	0.4849
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0026	0.7283	0.4581
Schistosoma mansoni	opsin-like receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus granulosus	g-protein coupled receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0026	0.7283	0.9819
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.7283	0.4581
Brugia malayi	sulfakinin receptor protein	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide receptor	0.0026	0.7283	0.4581
Brugia malayi	GnHR receptor homolog	0.0026	0.7283	0.4581
Echinococcus granulosus	allatostatin A receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	adenoreceptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	orexin receptor type 2	0.0026	0.7283	0.4581
Brugia malayi	larval opioid receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	neuropeptide receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	opsin-like receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	dro:myosuppressin receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Loa Loa (eye worm)	melatonin receptor type 1A	0.0026	0.7283	0.9819
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus granulosus	somatostatin receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Echinococcus granulosus	serine protein kinase ATM	0.003	1	1
Echinococcus multilocularis	sex peptide receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	neuropeptide F receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Echinococcus multilocularis	g-protein coupled receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.7283	0.9819
Brugia malayi	G protein-coupled receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.7283	0.9819
Brugia malayi	G protein-coupled receptor F59B2.13	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Brugia malayi	putative neuropeptide receptor NPR1	0.0026	0.7283	0.4581
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	somatostatin receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Schistosoma mansoni	opsin-like receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0026	0.7283	0.9819
Echinococcus granulosus	fmrfamide receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	G protein coupled receptor 139	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus multilocularis	serotonin receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	Dopamine receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.7283	0.4581
Toxoplasma gondii	FATC domain-containing protein	0.003	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus granulosus	g protein coupled receptor	0.0026	0.7283	0.4581
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0026	0.7283	0.4581
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Schistosoma mansoni	neuropeptide receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0026	0.7283	0.4581
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0026	0.7283	0.4581
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.4987	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.4987	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.7283	0.4581
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.4987	0.4987
Echinococcus multilocularis	serine protein kinase ATM	0.003	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	neuropeptide receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	G protein coupled receptor 139	0.0026	0.7283	0.4581
Echinococcus granulosus	7TM GPCR rhodopsin	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	neuropeptide FF receptor 2	0.0026	0.7283	0.4581
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0026	0.7283	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0026	0.7283	0.4581
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.7283	0.9819
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	neuropeptide receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0026	0.7283	0.4581
Echinococcus multilocularis	serotonin receptor	0.0026	0.7283	0.4581
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.7283	0.4581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Schistosoma mansoni	amine GPCR	0.0026	0.7283	0.4581
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	1	1
Onchocerca volvulus		0.0026	0.7283	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.4987	0.6723
Brugia malayi	putative neuropeptide receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.7283	0.4581
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Brugia malayi	ORL1-like opioid receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.7283	0.4581
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.7283	0.4581
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus granulosus	g protein coupled receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.4987	0.4987
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Echinococcus granulosus	sex peptide receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.7283	0.4581
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Brugia malayi	AKH receptor	0.0026	0.7283	0.4581
Onchocerca volvulus		0.0026	0.7283	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.7283	0.4581
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0026	0.7283	0.4581
Echinococcus granulosus	hypothetical protein	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Schistosoma mansoni	hypothetical protein	0.0026	0.7283	0.4581
Echinococcus granulosus	serotonin receptor	0.0026	0.7283	0.4581
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.7283	0.4581
Loa Loa (eye worm)	hypothetical protein	0.0026	0.7283	0.9819
Onchocerca volvulus		0.0026	0.7283	0.5
Schistosoma mansoni	biogenic amine receptor	0.0026	0.7283	0.4581
Echinococcus multilocularis	neuropeptide receptor A26	0.0026	0.7283	0.4581

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3294 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	1.4716 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5878 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1482108

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1340073