Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | pyruvate kinase | 0.004 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.6979 | 0.5671 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.004 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 1 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.004 | 1 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 1 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 1 | 0.5 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.004 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0028 | 0.5661 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.004 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.004 | 1 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0112 um | PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Pyruvate Kinase M2 isoform. (Class of assay: confirmatory) [Related pubchem assays: 1634, 1631 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.