Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | FMRFamide-gated Na+ channel | 0.0029 | 0.5498 | 0.5498 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Onchocerca volvulus | 0.0029 | 0.5498 | 0.5 | |
Loa Loa (eye worm) | amiloride-sensitive sodium channel | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.7495 | 0.8354 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.1028 | 0.1145 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0029 | 0.5498 | 0.5498 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.8236 | 1 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0042 | 0.8972 | 1 |
Brugia malayi | Degenerin-like protein ZK770.1 in chromosome I, putative | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0042 | 0.8972 | 1 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Loa Loa (eye worm) | degenerin unc-8 | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | acid sensing ion channel 4 pituitary | 0.0029 | 0.5498 | 0.5498 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | amiloride sensitive cation channel acid sensing ion channel pituitary | 0.0029 | 0.5498 | 0.6128 |
Brugia malayi | Degenerin-like protein C41C4.5 in chromosome II, putative | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Echinococcus granulosus | sodium channel nonvoltage gated 1 alpha | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0029 | 0.5498 | 0.5498 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.1028 | 0.1145 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0029 | 0.5498 | 0.6128 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0042 | 0.8972 | 1 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | amiloride sensitive sodium channel | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | sodium channel nonvoltage gated 1 alpha | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Brugia malayi | amiloride-sensitive sodium channel alpha-subunit, putative | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Echinococcus granulosus | amiloride sensitive cation channel | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | amiloride sensitive cation channel 4 A | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0045 | 1 | 1 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | Na channel amiloride sensitive | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.8972 | 1 |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | Na+ channel, amiloride sensitive | 0.0029 | 0.5498 | 0.6128 |
Loa Loa (eye worm) | amiloride-sensitive sodium channel family protein | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0029 | 0.5498 | 0.5498 |
Schistosoma mansoni | amiloride-sensitive sodium channel-related | 0.0029 | 0.5498 | 0.5498 |
Echinococcus multilocularis | protein vprbp | 0.0029 | 0.5498 | 0.6128 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.1028 | 0.1145 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.5498 | 0.5498 |
Brugia malayi | Degenerin unc-8 | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.1028 | 0.1028 |
Brugia malayi | Amiloride-sensitive sodium channel family protein | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.1028 | 0.1028 |
Brugia malayi | Degenerin mec-4 | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.8236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.5498 | 0.6128 |
Echinococcus multilocularis | FMRFamide activated amiloride sensitive sodium | 0.0029 | 0.5498 | 0.6128 |
Echinococcus granulosus | protein vprbp | 0.0029 | 0.5498 | 0.6128 |
Onchocerca volvulus | 0.0029 | 0.5498 | 0.5 | |
Echinococcus multilocularis | amiloride sensitive cation channel 4 A | 0.0029 | 0.5498 | 0.6128 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.