Detailed view for EmuJ_000251500

Basic information

TDR Targets ID: 965800
Echinococcus multilocularis, FMRFamide activated amiloride sensitive sodium
Source Database / ID:  GeneDB

pI: 8.379 | Length (AA): 202 | MW (Da): 23045 | Paralog Number: 7

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00858   Amiloride-sensitive sodium channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005272   sodium channel activity  
GO:0006814   sodium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
108 187 4nee (G) 77 155 33.00 0.84 0.31 0.55894 0.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_145150)

Species Accession Gene Product
Echinococcus granulosus EgrG_000526700   FMRFamide activated amiloride sensitive sodium
Echinococcus granulosus EgrG_002060300   amiloride sensitive sodium channel
Echinococcus granulosus EgrG_000738300   FMRFamide activated amiloride sensitive sodium
Echinococcus granulosus EgrG_000251600   FMRFamide activated amiloride sensitive sodium
Echinococcus granulosus EgrG_000763100   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000006300   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000006400   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000763100   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000251600   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000526700   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000738300   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000251500   FMRFamide activated amiloride sensitive sodium
Echinococcus multilocularis EmuJ_000093100   FMRFamide activated amiloride sensitive sodium
Schistosoma japonicum Sjp_0054910   expressed protein
Schistosoma japonicum Sjp_0037830   FMRFamide-activated amiloride-sensitive sodium channel, putative
Schistosoma japonicum Sjp_0052830   FMRFamide-activated amiloride-sensitive sodium channel, putative
Schistosoma japonicum Sjp_0052820   IPR001873,Na+ channel, amiloride-sensitive,domain-containing
Schistosoma japonicum Sjp_0095330   IPR001873,Na+ channel, amiloride-sensitive,domain-containing
Schistosoma japonicum Sjp_0010320   IPR001873,Na+ channel, amiloride-sensitive,domain-containing
Schistosoma japonicum Sjp_0120110   FMRFamide-activated amiloride-sensitive sodium channel, putative
Schistosoma japonicum Sjp_0054920   IPR001873,Na+ channel, amiloride-sensitive,domain-containing
Schistosoma mansoni Smp_144110   FMRFamide-gated Na+ channel
Schistosoma mansoni Smp_124040   hypothetical protein
Schistosoma mansoni Smp_052630   amiloride-sensitive sodium channel-related
Schistosoma mansoni Smp_162680   amiloride-sensitive sodium channel-related
Schistosoma mansoni Smp_093210   amiloride-sensitive sodium channel-related
Schistosoma mansoni Smp_180260   amiloride-sensitive sodium channel-related
Schistosoma mansoni Smp_178830   hypothetical protein
Schmidtea mediterranea mk4.000327.05   Putative fmrfamide-gated Na channel
Schmidtea mediterranea mk4.016043.00  
Schmidtea mediterranea mk4.012799.00   Putative amiloride-sensitive sodium channel
Schmidtea mediterranea mk4.003454.04  
Schmidtea mediterranea mk4.008402.01  
Schmidtea mediterranea mk4.007560.00   Amiloride-sensitive sodium channel,putative
Schmidtea mediterranea mk4.004838.00  
Schmidtea mediterranea mk4.001765.01  
Schmidtea mediterranea mk4.012973.00   Putative fmrfamide-gated Na channel
Schmidtea mediterranea mk4.014480.00   Putative amiloride-sensitive sodium channel
Schmidtea mediterranea mk4.015957.00  
Schmidtea mediterranea mk4.022190.00  
Schmidtea mediterranea mk4.000267.18  
Schmidtea mediterranea mk4.009501.01   Putative fmrfamide-gated Na channel
Schmidtea mediterranea mk4.006386.01  
Schmidtea mediterranea mk4.006591.00  
Schmidtea mediterranea mk4.002898.01  
Schmidtea mediterranea mk4.010398.01  
Schmidtea mediterranea mk4.001598.01   Putative amiloride-sensitive sodium channel

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.011 1 1
0.018 1 1
0.0029 0.6786 0.7563
0.0029 0.6661 0.7424
0.0154 0.5 0.5
0.003 0.3948 0.7511
0.003 0.703 0.7836
0.0156 1 1
0.0029 0.5498 0.6128
0.0092 0.722 1
0.0177 0.5 0.5
0.018 0.9868 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000251500 (Echinococcus multilocularis), FMRFamide activated amiloride sensitive sodium
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