Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0303 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0049 | 0.0049 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.5435 | 0.5435 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.5435 | 0.5412 |
Onchocerca volvulus | 0.0286 | 0.9378 | 0.9375 | |
Plasmodium falciparum | transporter, putative | 0.0303 | 1 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8082 | 0.8073 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.5435 | 0.5412 |
Plasmodium vivax | metal transporter, putative | 0.0303 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5435 | 0.5412 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0187 | 0.5686 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 1 | 1 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0303 | 1 | 1 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0187 | 0.5686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5435 | 0.5412 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0303 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.9378 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8082 | 0.8073 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0303 | 1 | 1 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0303 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.5435 | 0.5412 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0303 | 1 | 1 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0303 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0303 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 7.9433 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.