Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysosomal alpha glucosidase | 0.034 | 0.9724 | 0.971 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4914 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 1 | 1 |
Onchocerca volvulus | 0.0228 | 0.4904 | 0.4904 | |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.025 | 0.5854 | 0.564 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0202 | 0.3754 | 0.3432 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.034 | 0.9724 | 0.971 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0202 | 0.3754 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0919 | 0.045 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4914 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2515 | 0.3712 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Schistosoma mansoni | alpha-glucosidase | 0.034 | 0.9724 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0202 | 0.3754 | 0.3534 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.034 | 0.9724 | 0.971 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0346 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0202 | 0.3754 | 0.3432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2515 | 0.3712 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0346 | 1 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.025 | 0.5854 | 0.564 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0202 | 0.3754 | 0.3534 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0231 | 0.5028 | 0.5028 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0202 | 0.3754 | 0.3432 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0346 | 1 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0346 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0346 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0346 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0346 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0164 | 0.2132 | 0.2132 |
Brugia malayi | Ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Schistosoma mansoni | alpha-glucosidase | 0.034 | 0.9724 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0126 | 0.0491 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.034 | 0.9724 | 0.971 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.034 | 0.9724 | 0.971 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0346 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.