Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth factor, augmenter of liver regeneration | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0041 | 0.5 | 0.5 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0041 | 0.5 | 0.5 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0041 | 0.5 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0041 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.5 | 0.5 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0041 | 0.5 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0041 | 0.5 | 0.5 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0041 | 0.5 | 0.5 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0041 | 0.5 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0041 | 0.5 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0041 | 0.5 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0041 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 5.318 uM | PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.