Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ribonuclease H1, putative | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0027 | 0.0223 | 0.0309 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0976 | 0.0976 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.0223 | 0.0309 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.4072 | 0.3431 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4072 | 0.5632 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2644 | 0.1849 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4072 | 0.5632 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2644 | 0.2644 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.0223 | 0.0309 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | ribonuclease HI protein | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2644 | 0.1849 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4072 | 1 |
Giardia lamblia | Ribonuclease H | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0976 | 0.1349 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.4072 | 0.3431 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.4072 | 0.3431 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4072 | 0.5632 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4072 | 0.5632 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0064 | 0.4072 | 0.4072 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0025 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.4072 | 0.4072 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2644 | 0.2644 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0027 | 0.0223 | 0.0309 |
Trypanosoma brucei | RNA helicase, putative | 0.0094 | 0.723 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.4072 | 0.4072 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0027 | 0.0223 | 0.0309 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4072 | 0.5632 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4072 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.723 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.