Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1504 | 0.2765 | 0.2765 |
Brugia malayi | hypothetical protein | 0.0619 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.3065 | 0.7162 | 0.7162 |
Loa Loa (eye worm) | hypothetical protein | 0.1504 | 0.2765 | 0.2765 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1988 | 0.4129 | 0.4129 |
Leishmania major | hypothetical protein, conserved | 0.0522 | 0 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.3017 | 0.7027 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.4073 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0522 | 0 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0522 | 0 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.2398 | 0.5283 | 1 |
Brugia malayi | Kelch motif family protein | 0.0619 | 0.0271 | 0.0271 |
Schistosoma mansoni | integrin alpha-ps | 0.0891 | 0.1039 | 0.1967 |
Echinococcus granulosus | integrin alpha 3 | 0.1524 | 0.2822 | 0.4016 |
Echinococcus granulosus | integrin alpha ps | 0.0891 | 0.1039 | 0.1479 |
Echinococcus multilocularis | integrin alpha 3 | 0.1524 | 0.2822 | 0.4016 |
Loa Loa (eye worm) | hypothetical protein | 0.0619 | 0.0271 | 0.0271 |
Echinococcus multilocularis | integrin alpha ps | 0.0891 | 0.1039 | 0.1479 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0522 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1097 | 0.1618 | 0.1618 |
Schistosoma mansoni | integrin alpha | 0.1988 | 0.4129 | 0.7815 |
Onchocerca volvulus | 0.0522 | 0 | 0.5 | |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0619 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.1561 | 0.2925 | 0.2925 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0522 | 0 | 0.5 |
Echinococcus multilocularis | integrin alpha ps | 0.0891 | 0.1039 | 0.1479 |
Echinococcus granulosus | integrin beta 2 | 0.3017 | 0.7027 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.9285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.