Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2682 | 0.2682 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0054 | 0.2587 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2682 | 0.3737 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2682 | 0.3737 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2682 | 0.2682 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1639 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1639 | 0.1639 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0054 | 0.2587 | 0.2587 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0054 | 0.2587 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0054 | 0.2587 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7177 | 0.7177 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0054 | 0.2587 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.7177 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.7177 | 0.7177 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2682 | 0.2682 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2587 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2682 | 0.2682 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0177 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.013 | 0.7177 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.7177 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2682 | 0.2682 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0054 | 0.2587 | 0.5 |
Brugia malayi | TAR-binding protein | 0.013 | 0.7177 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1639 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0054 | 0.2587 | 0.2587 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.7177 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1639 | 0.2283 |
Trypanosoma brucei | protein kinase, putative | 0.0054 | 0.2587 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7177 | 0.7177 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1639 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0054 | 0.2587 | 0.2587 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0054 | 0.2587 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0054 | 0.2587 | 0.2587 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.7177 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2587 | 0.5 |
Brugia malayi | MAP kinase sur-1 | 0.0054 | 0.2587 | 0.3605 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0054 | 0.2587 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7177 | 0.7177 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0054 | 0.2587 | 0.2587 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1639 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0054 | 0.2587 | 0.3605 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.2587 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7177 | 0.7177 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1639 | 0.1639 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0054 | 0.2587 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2587 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1639 | 0.1639 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2682 | 0.2682 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1639 | 0.1639 |
Echinococcus multilocularis | tar DNA binding protein | 0.013 | 0.7177 | 0.7177 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2682 | 0.2682 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0054 | 0.2587 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.013 | 0.7177 | 0.7177 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.