Detailed information for compound 1354498

Basic information

Technical information
  • TDR Targets ID: 1354498
  • Name: N-[(2-chlorophenyl)methyl]-3-[2,4-dioxo-1-[2- oxo-2-(phenylamino)ethyl]thieno[3,2-d]pyrimid in-3-yl]propanamide
  • MW: 496.966 | Formula: C24H21ClN4O4S
  • H donors: 2 H acceptors: 4 LogP: 3.1 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCn1c(=O)n(CC(=O)Nc2ccccc2)c2c(c1=O)scc2)NCc1ccccc1Cl
  • InChi: 1S/C24H21ClN4O4S/c25-18-9-5-4-6-16(18)14-26-20(30)10-12-28-23(32)22-19(11-13-34-22)29(24(28)33)15-21(31)27-17-7-2-1-3-8-17/h1-9,11,13H,10,12,14-15H2,(H,26,30)(H,27,31)
  • InChiKey: ZGKRJBCLCDUOFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-chlorophenyl)methyl]-3-[2,4-dioxo-1-[2-oxo-2-(phenylamino)ethyl]-3-thieno[3,2-d]pyrimidinyl]propanamide
  • N-(2-chlorobenzyl)-3-[2,4-diketo-1-[2-keto-2-(phenylamino)ethyl]thieno[3,2-d]pyrimidin-3-yl]propionamide
  • C241-2061
  • NCGC00105946-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.6922 0.6922
Brugia malayi hypothetical protein 0.002 0.0402 0.0402
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.3393 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3945 0.3945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3078 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3855 0.3855
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.3393 0.5
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.6934 0.6934
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.3393 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.6922 0.6922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.6922 0.6922
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 1 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3066 0.3066
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.78 0.78
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.6145 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.1204 0.1204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3855 0.3855
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.6934 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Loa Loa (eye worm) hypothetical protein 0.003 0.3393 0.3393
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.207 0.207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3078 0.3078
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3066 0.3066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 1 1
Giardia lamblia GTOR 0.0054 1 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.3393 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3066 0.3066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3945 0.3945
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.3945 0.3945
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.6934 0.6934
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3078 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.6922 0.6922
Brugia malayi hypothetical protein 0.003 0.3393 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.6922 0.6922
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 1 1
Leishmania major hypothetical protein, conserved 0.003 0.3393 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.4722 0.4722
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 1 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.3393 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.6145 0.6145
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.3393 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.3078 0.3078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.5047 0.5047

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0037 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.2809 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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