Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2082 | 0.3335 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0024 | 0.0103 | 0.0309 |
Brugia malayi | MH2 domain containing protein | 0.0136 | 0.6244 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.2741 | 0.2741 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.0103 | 0.0309 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.2741 | 0.439 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.2741 | 0.3272 |
Trypanosoma brucei | RNA helicase, putative | 0.0083 | 0.335 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1038 | 0.1038 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.2741 | 0.3272 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0024 | 0.0103 | 0.0309 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0024 | 0.0103 | 0.0309 |
Giardia lamblia | Ribonuclease H | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 0.6244 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.2741 | 0.3272 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2741 | 0.2741 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2741 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2082 | 0.2006 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0024 | 0.0103 | 0.0309 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2082 | 0.3335 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2741 | 0.2741 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2741 | 0.2741 |
Toxoplasma gondii | ribonuclease HI protein | 0.0022 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0072 | 0.2741 | 0.439 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.2741 | 0.439 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2082 | 0.2006 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2741 | 0.2741 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 0.6244 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.2741 | 0.2741 |
Leishmania major | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0022 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1038 | 0.1662 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.335 | 0.335 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8356 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.