Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | histone deacetylase 1 (HD1) | 0.1891 | 0.9913 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.1866 | 0.9768 | 0.9758 |
Trypanosoma brucei | histone deacetylase 4 | 0.1866 | 0.9768 | 0.9758 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.1866 | 0.9768 | 0.9758 |
Leishmania major | histone deacetylase, putative | 0.1891 | 0.9913 | 1 |
Schistosoma mansoni | histone deacetylase | 0.1891 | 0.9913 | 0.9913 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1891 | 0.9913 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.1891 | 0.9913 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0851 | 0.3944 | 0.3944 |
Brugia malayi | Histone deacetylase family protein | 0.1866 | 0.9768 | 0.9758 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.1891 | 0.9913 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.1866 | 0.9768 | 0.9758 |
Echinococcus granulosus | histone deacetylase 6 | 0.1866 | 0.9768 | 0.9618 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1866 | 0.9768 | 0.9768 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1866 | 0.9768 | 0.9768 |
Echinococcus multilocularis | histone deacetylase 3 | 0.1891 | 0.9913 | 0.9913 |
Echinococcus granulosus | histone deacetylase 7 | 0.1866 | 0.9768 | 0.9618 |
Plasmodium falciparum | histone deacetylase 1 | 0.1891 | 0.9913 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1907 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.1866 | 0.9768 | 0.9618 |
Loa Loa (eye worm) | hypothetical protein | 0.1891 | 0.9913 | 1 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0851 | 0.3944 | 0.3944 |
Echinococcus multilocularis | histone deacetylase | 0.1866 | 0.9768 | 0.9768 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1891 | 0.9913 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1055 | 0.5114 | 0.196 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Trypanosoma brucei | histone deacetylase, putative | 0.1866 | 0.9768 | 0.9758 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1891 | 0.9913 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.1891 | 0.9913 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.1891 | 0.9913 | 1 |
Echinococcus granulosus | histone deacetylase | 0.1866 | 0.9768 | 0.9618 |
Plasmodium vivax | histone deacetylase 2, putative | 0.1866 | 0.9768 | 0.9758 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.1891 | 0.9913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1015 | 0.4882 | 0.1573 |
Echinococcus multilocularis | histone deacetylase 1 | 0.1891 | 0.9913 | 0.9913 |
Entamoeba histolytica | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1866 | 0.9768 | 0.9758 |
Plasmodium vivax | histone deacetylase 1, putative | 0.1891 | 0.9913 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.1866 | 0.9768 | 0.9758 |
Loa Loa (eye worm) | histone deacetylase | 0.1866 | 0.9768 | 0.9758 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1866 | 0.9768 | 0.9758 |
Giardia lamblia | Histone deacetylase | 0.1891 | 0.9913 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.1866 | 0.9768 | 0.9758 |
Echinococcus multilocularis | histone deacetylase 7 | 0.1866 | 0.9768 | 0.9768 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.1866 | 0.9768 | 0.9768 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0851 | 0.3944 | 0.3944 |
Echinococcus multilocularis | histone deacetylase 6 | 0.1866 | 0.9768 | 0.9768 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0851 | 0.3944 | 0.5 |
Plasmodium vivax | histone deacetylase, putative | 0.1866 | 0.9768 | 0.9758 |
Schistosoma mansoni | histone deacetylase | 0.1891 | 0.9913 | 0.9913 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.1891 | 0.9913 | 1 |
Leishmania major | histone deacetylase, putative | 0.1891 | 0.9913 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.1891 | 0.9913 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.1891 | 0.9913 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.1891 | 0.9913 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.1907 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.1891 | 0.9913 | 0.5 |
Echinococcus granulosus | histone deacetylase 1 | 0.1891 | 0.9913 | 0.9856 |
Echinococcus granulosus | histone deacetylase 3 | 0.1891 | 0.9913 | 0.9856 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.