Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.2229 | 0.0936 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.2229 | 0.0936 |
Trypanosoma brucei | protein arginine n-methyltransferase 7 | 0.0141 | 0.1426 | 1 |
Onchocerca volvulus | 0.0114 | 0.0869 | 0.5 | |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.2003 | 0.0674 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.2229 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0561 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.2003 | 0.0674 |
Toxoplasma gondii | hypothetical protein | 0.0071 | 0 | 0.5 |
Echinococcus multilocularis | histone h3 methyltransferase | 0.0561 | 1 | 1 |
Trypanosoma cruzi | protein arginine n-methyltransferase 7 | 0.0141 | 0.1426 | 1 |
Leishmania major | arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 | 0.0141 | 0.1426 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.2563 | 0.1326 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.2563 | 0.1326 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2229 | 0.0936 |
Echinococcus granulosus | histone h3 methyltransferase | 0.0561 | 1 | 1 |
Schistosoma mansoni | histone J3 methyltransferase | 0.0561 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.2563 | 0.1326 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.2563 | 0.1326 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.2229 | 0.0936 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.2229 | 0.0936 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.2563 | 0.1326 |
Trypanosoma cruzi | arginine N-methyltransferase, type III | 0.0141 | 0.1426 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.4 uM | PUBCHEM_BIOASSAY: Dose response for HTS for Beta-2AR agonists via FAP method from CP1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID492947, AID504448] | ChEMBL. | No reference |
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (binding) | 11.2202 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.