Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0036 | 0.0789 | 0.0995 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.2807 | 0.3543 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.6016 | 0.5896 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2696 | 0.3404 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0789 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0789 | 0.0511 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.7922 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.2807 | 0.3543 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0789 | 0.0511 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0293 | 0.0369 |
Onchocerca volvulus | 0.0054 | 0.2807 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2807 | 0.3543 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.4391 | 0.5542 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0789 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.2807 | 0.259 |
Echinococcus multilocularis | musashi | 0.0054 | 0.2807 | 0.259 |
Schistosoma mansoni | lamin | 0.0054 | 0.2807 | 0.259 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0789 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.2807 | 0.3543 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.4391 | 0.5542 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0293 | 0.0369 |
Echinococcus granulosus | lamin | 0.0054 | 0.2807 | 0.259 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0293 | 0.0369 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.2807 | 0.259 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.7922 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.2807 | 0.259 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.2807 | 0.3543 |
Onchocerca volvulus | 0.0054 | 0.2807 | 0.5 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.7922 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.2807 | 0.259 |
Schistosoma mansoni | lamin | 0.0054 | 0.2807 | 0.259 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0789 | 0.0511 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0789 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.7922 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0293 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.4391 | 0.4222 |
Echinococcus multilocularis | lamin | 0.0054 | 0.2807 | 0.259 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0789 | 0.0511 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 um | PUBCHEM_BIOASSAY: In Vitro Bfl-1 Dose Response Fluorescence Polarization Assay for SAR Study. (Class of assay: confirmatory) [Related pubchem assays: 621, 432 ] | ChEMBL. | No reference |
IC50 (binding) | > 100 um | PUBCHEM_BIOASSAY: TR-FRET secondary assay for HTS discovery of chemical inhibitors of anti-apoptotic protein Bfl-1. (Class of assay: confirmatory) [Related pubchem assays: 432 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.