Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | gabp alpha | 0.0087 | 0.1797 | 0.1445 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0411 | 0.0435 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.1797 | 1 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 0.7409 | 0.7844 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.1797 | 1 |
Schistosoma mansoni | ets-related | 0.0265 | 0.7409 | 0.7298 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.9445 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.9445 | 1 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.9445 | 1 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.9445 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0411 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0411 | 0.0435 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0411 | 0.0435 |
Onchocerca volvulus | 0.0043 | 0.0411 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0411 | 0.0435 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0411 | 0.0435 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0411 | 1 |
Schistosoma mansoni | glutaminase | 0.033 | 0.9445 | 0.9421 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0411 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0411 | 0.0435 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0166 | 0.426 | 0.426 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0411 | 0.0435 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0411 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0411 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.9445 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1397 | 0.1479 |
Brugia malayi | Fli-1 protein | 0.0265 | 0.7409 | 0.7844 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0411 | 0.0435 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0411 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0411 | 0.0435 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0411 | 0.0435 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0411 | 0.0435 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0411 | 0.0435 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.1797 | 0.1902 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.1797 | 0.1902 |
Onchocerca volvulus | 0.0043 | 0.0411 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0411 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.1797 | 0.1902 |
Onchocerca volvulus | 0.0043 | 0.0411 | 0.5 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.7796 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.