Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.2629 | 0.2629 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.84 | 0.84 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2629 | 0.2629 |
Giardia lamblia | High cysteine protein | 0.0038 | 0 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0044 | 0.3072 | 0.3072 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.84 | 0.84 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3072 | 0.3072 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2629 | 0.2629 |
Onchocerca volvulus | 0.0059 | 1 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2629 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.84 | 0.84 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2629 | 0.2629 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.84 | 0.84 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0044 | 0.3072 | 0.3072 |
Brugia malayi | Kringle domain containing protein | 0.0059 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0044 | 0.3072 | 0.3072 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.84 | 0.84 |
Schistosoma mansoni | egf-like domain protein | 0.0044 | 0.3072 | 0.3072 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3072 | 0.3072 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0044 | 0.3072 | 0.3072 |
Echinococcus multilocularis | laminin | 0.0044 | 0.3072 | 0.3072 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0059 | 1 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0044 | 0.3072 | 0.3072 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0044 | 0.3072 | 0.3072 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2629 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0044 | 0.3072 | 0.3072 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0044 | 0.3072 | 0.3072 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0044 | 0.3072 | 0.3072 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0044 | 0.3072 | 0.3072 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3072 | 0.3072 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2629 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.84 | 0.84 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.84 | 0.84 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0059 | 1 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0044 | 0.3072 | 0.3072 |
Leishmania major | hypothetical protein, conserved | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3072 | 0.3072 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2629 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0059 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0059 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0059 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0059 | 1 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.84 | 0.84 |
Brugia malayi | Fibulin-1 precursor | 0.0044 | 0.3072 | 0.3072 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.84 | 0.84 |
Echinococcus granulosus | laminin | 0.0044 | 0.3072 | 0.3072 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2629 | 0.2629 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3072 | 0.3072 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0044 | 0.3072 | 0.3072 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.