Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K09435 transcriptional regulator ERG, putative | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma mansoni | ets-related | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Brugia malayi | Fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Loa Loa (eye worm) | fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1091 | 0.726 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1035 | 0.6766 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0668 | 0.3536 | 0.261 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1091 | 0.726 | 0.6868 |
Brugia malayi | amidase | 0.0668 | 0.3536 | 0.487 |
Schistosoma mansoni | amidase | 0.0668 | 0.3536 | 0.5226 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1091 | 0.726 | 0.6868 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0668 | 0.3536 | 0.5226 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0848 | 0.5124 | 0.7573 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0668 | 0.3536 | 0.261 |
Onchocerca volvulus | 0.0857 | 0.5196 | 0.5 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1091 | 0.726 | 0.6868 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1403 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0668 | 0.3536 | 0.261 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0848 | 0.5124 | 0.7057 |
Schistosoma mansoni | alpha-glucosidase | 0.1035 | 0.6766 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1403 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.3536 | 0.487 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0848 | 0.5124 | 0.7057 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1091 | 0.726 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0372 | 0.0938 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0668 | 0.3536 | 0.261 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0372 | 0.0938 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.