Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | ATP phosphoribosyltransferase HisG | 0.0348 | 1 | 1 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.0071 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0226 | 0.5789 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.2146 | 0.3708 |
Mycobacterium ulcerans | ATP phosphoribosyltransferase | 0.0348 | 1 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.0071 | 0.0123 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0226 | 0.5789 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.5901 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.5053 | 0.8728 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0071 | 0.0123 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5053 | 0.8728 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.5053 | 0.8728 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0071 | 0.0121 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5053 | 0.8728 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.4287 | 0.7265 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.5901 | 1 |
Onchocerca volvulus | 0.0182 | 0.4287 | 1 | |
Schistosoma mansoni | lipoxygenase | 0.0226 | 0.5789 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0071 | 0.0123 |
Brugia malayi | hypothetical protein | 0.0182 | 0.4287 | 0.7265 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.