Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0067 | 0.3214 | 1 |
Echinococcus granulosus | expressed protein | 0.0067 | 0.3214 | 1 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0067 | 0.3214 | 0.3214 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.3125 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.002 | 0.0594 | 0.1899 |
Schistosoma mansoni | rotamase | 0.0067 | 0.3214 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0067 | 0.3214 | 1 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.002 | 0.0594 | 0.1899 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0065 | 0.3125 | 1 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0 | 0.5 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0 | 0.5 |
Toxoplasma gondii | PPIC-type PPIASE domain-containing protein | 0.002 | 0.0594 | 0.1899 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.002 | 0.0594 | 1 |
Loa Loa (eye worm) | WEE protein kinase | 0.0186 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.002 | 0.0594 | 0.1899 |
Echinococcus multilocularis | expressed protein | 0.0067 | 0.3214 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0065 | 0.3125 | 1 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0065 | 0.3125 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0065 | 0.3125 | 1 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Chlamydia trachomatis | DNA ligase | 0.001 | 0 | 0.5 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0065 | 0.3125 | 1 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0 | 0.5 |
Trichomonas vaginalis | rotamase, putative | 0.0065 | 0.3125 | 0.9724 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0067 | 0.3214 | 0.3214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.