Detailed information for compound 1375134

Basic information

Technical information
  • TDR Targets ID: 1375134
  • Name: [5-[(4-bromophenyl)sulfonylmethyl]furan-2-yl] -(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methano ne
  • MW: 470.334 | Formula: C19H20BrNO6S
  • H donors: 0 H acceptors: 3 LogP: 2.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)S(=O)(=O)Cc1ccc(o1)C(=O)N1CCC2(CC1)OCCO2
  • InChi: 1S/C19H20BrNO6S/c20-14-1-4-16(5-2-14)28(23,24)13-15-3-6-17(27-15)18(22)21-9-7-19(8-10-21)25-11-12-26-19/h1-6H,7-13H2
  • InChiKey: XPFBLBCOLVAGKS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [5-[(4-bromophenyl)sulfonylmethyl]-2-furyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
  • MLS000877116
  • 8-(5-{[(4-bromophenyl)sulfonyl]methyl}-2-furoyl)-1,4-dioxa-8-azaspiro[4.5]decane
  • MLS000095150
  • SMR000030704

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.1389 0.6562 0.6673
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.1497
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.2055 0.9806 1
Echinococcus multilocularis histone deacetylase 3 0.0186 0.0702 0.0664
Plasmodium falciparum histone deacetylase 1 0.0186 0.0702 0.207
Trichomonas vaginalis conserved hypothetical protein 0.0696 0.3185 0.267
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Loa Loa (eye worm) hypothetical protein 0.0194 0.074 0.0801
Toxoplasma gondii hypothetical protein 0.0696 0.3185 0.42
Loa Loa (eye worm) hypothetical protein 0.1768 0.8404 0.9758
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Plasmodium falciparum GAF domain-related protein, putative 0.0696 0.3185 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0186 0.0702 0.0664
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0666 0.3038 0.3487
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.2093 0.1497
Echinococcus granulosus histone deacetylase 1 0.0186 0.0702 0.0664
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0472 0.2093 0.6514
Echinococcus granulosus geminin 0.0177 0.0656 0.0618
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0831 0.3841 0.3884
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0576 0.26 0.2611
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.181 0.8611 0.8781
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0831 0.3841 0.3884
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0736 0.3379 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2095 1 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1498 0.709 0.8222
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.1389 0.6562 0.7605
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0831 0.3841 0.5081
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0831 0.3841 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0895 0.4156 0.4206
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1168 0.5483 0.5142
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0736 0.3379 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.0874 0.0958
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0423 0.1858 0.185
Toxoplasma gondii histone deacetylase HDAC3 0.0186 0.0702 0.0869
Schistosoma mansoni hypothetical protein 0.0177 0.0656 0.0669
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0472 0.2093 0.2135
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0512 0.2287 0.1705
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0472 0.2093 0.1497
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0576 0.26 0.2611
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0472 0.2093 0.1497
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0472 0.2093 0.2091
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Trichomonas vaginalis conserved hypothetical protein 0.1584 0.7508 0.732
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0576 0.26 0.2976
Trypanosoma cruzi histone deacetylase 1, putative 0.0186 0.0702 0.0664
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.2055 0.9806 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0472 0.2093 0.1497
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0472 0.2093 0.2135
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0472 0.2093 0.1497
Entamoeba histolytica histone deacetylase, putative 0.0186 0.0702 0.5
Loa Loa (eye worm) hypothetical protein 0.1296 0.6106 0.7073
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.1359 0.6417 0.6146
Toxoplasma gondii histone deacetylase HDAC2 0.0186 0.0702 0.0869
Trichomonas vaginalis conserved hypothetical protein 0.2095 1 1
Brugia malayi hypothetical protein 0.0084 0.0203 0.0174
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Trypanosoma cruzi hypothetical protein, conserved 0.0472 0.2093 0.2091
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.1168 0.5483 0.5142
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Loa Loa (eye worm) hypothetical protein 0.1498 0.709 0.8222
Trypanosoma cruzi UNC119 0.0084 0.0203 0.0152
Trypanosoma brucei histone deacetylase 1 0.0186 0.0702 0.0664
Leishmania major hypothetical protein, conserved 0.0084 0.0203 0.0152
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.6514
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0831 0.3841 0.3884
Loa Loa (eye worm) hypothetical protein 0.0666 0.3038 0.3487
Brugia malayi Histone deacetylase 1 0.0186 0.0702 0.0757
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0423 0.1858 0.2108
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0423 0.1858 0.2108
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0585 0.2645 0.2657
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.2055 0.9806 0.9792
Schistosoma mansoni retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase 0.0414 0.1812 0.1848
Brugia malayi hypothetical protein 0.0414 0.1812 0.2055
Plasmodium falciparum phosphodiesterase delta, putative 0.0472 0.2093 0.6514
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0898 0.4168 0.5519
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0472 0.2093 0.2135
Leishmania major hypothetical protein, conserved 0.0472 0.2093 0.2091
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0585 0.2645 0.8276
Echinococcus granulosus histone deacetylase 3 0.0186 0.0702 0.0664
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0585 0.2645 0.2657
Loa Loa (eye worm) hypothetical protein 0.0084 0.0203 0.0174
Schistosoma mansoni hypothetical protein 0.0576 0.26 0.2652
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.1168 0.5483 0.5142
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0895 0.4156 1
Trichomonas vaginalis conserved hypothetical protein 0.1584 0.7508 0.732
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.1359 0.6417 0.6524
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0666 0.3038 0.3487
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.2093 0.1497
Toxoplasma gondii hypothetical protein 0.0696 0.3185 0.42
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0472 0.2093 0.2135
Leishmania major cAMP-specific phosphodiesterase, putative 0.0472 0.2093 0.2091
Loa Loa (eye worm) hypothetical protein 0.0414 0.1812 0.2055
Echinococcus multilocularis geminin 0.0177 0.0656 0.0618
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.2091
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.1497
Trypanosoma cruzi hypothetical protein, conserved 0.0472 0.2093 0.2091
Plasmodium vivax phosphodiesterase gamma, putative 0.0472 0.2093 0.5385
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.1257 0.5918 0.6013
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Schistosoma mansoni hypothetical protein 0.0576 0.26 0.2652
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0472 0.2093 0.2091
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.2055 0.9806 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0053 0.0054 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.2055 0.9806 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Trichomonas vaginalis conserved hypothetical protein 0.1584 0.7508 0.732
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Schistosoma mansoni histone deacetylase 0.0186 0.0702 0.0716
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.2055 0.9806 1
Trypanosoma cruzi hypothetical protein, conserved 0.0472 0.2093 0.2091
Brugia malayi histone deacetylase 1 (HD1) 0.0186 0.0702 0.0757
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0831 0.3841 0.5081
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2095 1 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0472 0.2093 0.2135
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.1498 0.709 0.723
Trypanosoma cruzi hypothetical protein, conserved 0.0472 0.2093 0.2091
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.181 0.8611 0.8775
Mycobacterium leprae conserved hypothetical protein 0.0696 0.3185 0.5
Loa Loa (eye worm) histone deacetylase 3 0.0186 0.0702 0.0757
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.2055 0.9806 0.9792
Plasmodium falciparum phosphodiesterase gamma, putative 0.0472 0.2093 0.6514
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1768 0.8404 0.9758
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0512 0.2287 0.1705
Trypanosoma brucei cAMP-specific phosphodiesterase 0.2055 0.9806 1
Schistosoma mansoni histone deacetylase 0.0186 0.0702 0.0716
Loa Loa (eye worm) hypothetical protein 0.0194 0.074 0.0801
Trypanosoma cruzi hypothetical protein, conserved 0.0472 0.2093 0.2091
Trypanosoma cruzi UNC119 0.0084 0.0203 0.0152
Trypanosoma brucei UNC119 0.0084 0.0203 0.0152
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.1497
Brugia malayi histone deacetylase 3 (HD3) 0.0186 0.0702 0.0757
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Giardia lamblia Hypothetical protein 0.0472 0.2093 0.4783
Loa Loa (eye worm) hypothetical protein 0.0895 0.4156 0.4793
Brugia malayi indoleamine 2,3-dioxygenase 0.0576 0.26 0.2976
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.1257 0.5918 0.6013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0054 0.0055
Plasmodium vivax histone deacetylase 1, putative 0.0186 0.0702 0.1711
Trypanosoma cruzi hypothetical protein, conserved 0.0472 0.2093 0.2091
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.2091
Loa Loa (eye worm) hypothetical protein 0.0917 0.4264 0.4919
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.2055 0.9806 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.074 0.0801
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0472 0.2093 0.2091
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0585 0.2645 0.2697
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0895 0.4156 0.4206
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0054 0.0055
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0831 0.3841 0.3884
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Loa Loa (eye worm) PDE1B protein 0.181 0.8611 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.2055 0.9806 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0895 0.4156 0.4206
Trypanosoma brucei hypothetical protein, conserved 0.0472 0.2093 0.2091
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0895 0.4156 0.4206
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.5385
Loa Loa (eye worm) histone deacetylase 1 0.0186 0.0702 0.0757
Schistosoma mansoni histone deacetylase 1 2 3 0.0053 0.0054 0.0055
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.1497
Leishmania major histone deacetylase, putative 0.0186 0.0702 0.0664
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0831 0.3841 0.3884
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0423 0.1858 0.185
Leishmania major hypothetical protein, conserved 0.0472 0.2093 0.2091
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0054 0.0055
Toxoplasma gondii GAF domain-containing protein 0.0696 0.3185 0.42
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.181 0.8611 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0472 0.2093 0.5385
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0474 0.2106 0.2753
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Loa Loa (eye worm) hypothetical protein 0.0186 0.0702 0.0757
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0472 0.2093 0.2736
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0054 0.0055
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.181 0.8611 0.8775
Giardia lamblia Histone deacetylase 0.0186 0.0702 0.1263
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0895 0.4156 0.4238
Giardia lamblia hypothetical protein 0.0472 0.2093 0.4783
Echinococcus multilocularis histone deacetylase 1 0.0186 0.0702 0.0664
Schistosoma mansoni amine GPCR 0.018 0.0673 0.0686
Trichomonas vaginalis retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase, putative 0.0414 0.1812 0.1194
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0831 0.3841 0.3884
Plasmodium vivax hypothetical protein, conserved 0.0696 0.3185 0.8267
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.1359 0.6417 0.6146
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.2055 0.9806 0.9792
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.1389 0.6562 0.6673
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0472 0.2093 0.6514
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0666 0.3038 0.3098
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2055 0.9806 0.9792
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0472 0.2093 0.2383
Leishmania major histone deacetylase, putative 0.0186 0.0702 0.0664
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0585 0.2645 0.3476
Schistosoma mansoni hypothetical protein 0.0177 0.0656 0.0669
Toxoplasma gondii hypothetical protein 0.1584 0.7508 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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