Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0312 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0369 | 0.0267 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0105 | 0.0105 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0312 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0369 | 0.0267 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0105 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0105 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0105 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0103 | 0.2849 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0103 | 0.2849 | 0.2774 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0369 | 0.0963 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0103 | 0.2849 | 1 |
Toxoplasma gondii | cathepsin B | 0.0103 | 0.2849 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0103 | 0.2849 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0103 | 0.2849 | 0.2774 |
Brugia malayi | hypothetical protein | 0.003 | 0.0369 | 0.0369 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0103 | 0.2849 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0312 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0369 | 0.0963 |
Giardia lamblia | Cathepsin B precursor | 0.0103 | 0.2849 | 1 |
Echinococcus granulosus | cathepsin b | 0.0312 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0312 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0369 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0369 | 0.0267 |
Echinococcus multilocularis | cathepsin b | 0.0312 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0105 | 0.5 |
Echinococcus multilocularis | cathepsin b | 0.0312 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0103 | 0.2849 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0369 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0105 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0369 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0369 | 0.0963 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0103 | 0.2849 | 0.2774 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0398 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1122 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.