Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 1 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | 0.0012 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 1 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.