Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0186 | 0 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0186 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0242 | 0.2691 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.0242 | 0.2691 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0186 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0242 | 0.2691 | 1 |
Plasmodium falciparum | plasmepsin X | 0.0242 | 0.2691 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0242 | 0.2691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0186 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.