Detailed information for compound 138284

Basic information

Technical information
  • TDR Targets ID: 138284
  • Name: N,N'-bis(3-phenylpropyl)-N,N'-bis[3-(3-phenyl propylamino)propyl]butane-1,4-diamine
  • MW: 675.043 | Formula: C46H66N4
  • H donors: 2 H acceptors: 0 LogP: 10.12 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 2
  • SMILES: N(CCCc1ccccc1)CCCN(CCCc1ccccc1)CCCCN(CCCc1ccccc1)CCCNCCCc1ccccc1
  • InChi: 1S/C46H66N4/c1-5-21-43(22-6-1)29-15-33-47-35-19-41-49(39-17-31-45-25-9-3-10-26-45)37-13-14-38-50(40-18-32-46-27-11-4-12-28-46)42-20-36-48-34-16-30-44-23-7-2-8-24-44/h1-12,21-28,47-48H,13-20,29-42H2
  • InChiKey: FHTXMIMSGWRIMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-phenylpropyl-[3-(3-phenylpropylamino)propyl]-[4-[3-phenylpropyl-[3-(3-phenylpropylamino)propyl]amino]butyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi trypanothione reductase, putative Starlite/ChEMBL References
Rattus norvegicus Glutamate NMDA receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast trypanothione reductase, putative 492 aa 548 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major acetoin dehydrogenase e3 component-like protein 0.00263827 0.0374353 0.103053
Echinococcus multilocularis carbonic anhydrase 0.0121416 0.363262 0.37728
Echinococcus granulosus tyrosine protein kinase Src64B 0.002125 0.0198378 0.0206032
Loa Loa (eye worm) thioredoxin reductase 0.00761339 0.20801 0.20801
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.00263827 0.0374353 0.0388798
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0121416 0.363262 0.37728
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.00208196 0.0183621 0.0183621
Echinococcus multilocularis tyrosine protein kinase Src42A 0.002125 0.0198378 0.0206032
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00263827 0.0374353 0.103053
Brugia malayi Variant SH3 domain containing protein 0.00208196 0.0183621 0.0190706
Plasmodium falciparum glutathione reductase 0.00761339 0.20801 0.572617
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00263827 0.0374353 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.002125 0.0198378 0.0206032
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.002125 0.0198378 0.0198378
Leishmania major carbonic anhydrase-like protein 0.0121416 0.363262 1
Onchocerca volvulus Putative fad oxidoreductase 0.0015464 0 0.5
Trichomonas vaginalis mercuric reductase, putative 0.00263827 0.0374353 0.5
Schistosoma mansoni tyrosine kinase 0.002125 0.0198378 0.0198378
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0121416 0.363262 1
Echinococcus granulosus carbonic anhydrase 0.0121416 0.363262 0.37728
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0307132 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.002125 0.0198378 0.0206032
Loa Loa (eye worm) carbonic anhydrase 3 0.0121416 0.363262 0.363262
Echinococcus multilocularis carbonic anhydrase II 0.0121416 0.363262 0.37728
Echinococcus granulosus tyrosine protein kinase Btk29A 0.002125 0.0198378 0.0206032
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.002125 0.0198378 0.0206032
Trichomonas vaginalis glutathione reductase, putative 0.00263827 0.0374353 0.5
Leishmania major dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00263827 0.0374353 0.103053
Loa Loa (eye worm) glutathione reductase 0.00761339 0.20801 0.20801
Brugia malayi Variant SH3 domain containing protein 0.00208196 0.0183621 0.0190706
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.002125 0.0198378 0.0206032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.00263827 0.0374353 0.103053
Schistosoma mansoni growth factor receptor-bound protein 0.0296295 0.962846 0.962846
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.00263827 0.0374353 0.0374353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0121416 0.363262 0.37728
Echinococcus multilocularis carbonic anhydrase 0.0121416 0.363262 0.37728
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.00263827 0.0374353 0.0388798
Echinococcus granulosus thioredoxin glutathione reductase 0.00761339 0.20801 0.216037
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.00263827 0.0374353 0.103053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.00761339 0.20801 0.219656
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.00193798 0.0134258 0.0139439
Schistosoma mansoni carbonic anhydrase-related 0.0121416 0.363262 0.363262
Echinococcus granulosus c src tyrosine kinase 0.002125 0.0198378 0.0206032
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.00263827 0.0374353 0.0388798
Trypanosoma brucei carbonic anhydrase-like protein 0.0121416 0.363262 1
Schistosoma mansoni tyrosine kinase 0.002125 0.0198378 0.0198378
Plasmodium falciparum glutathione reductase 0.00263827 0.0374353 0.103053
Schistosoma mansoni carbonic anhydrase-related 0.0121416 0.363262 0.363262
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.00263827 0.0374353 0.0395312
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0121416 0.363262 0.37728
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.002125 0.0198378 0.0206032
Echinococcus granulosus tyrosine protein kinase Fyn 0.002125 0.0198378 0.0206032
Schistosoma mansoni d-amino acid oxidase 0.0307132 1 1
Loa Loa (eye worm) hypothetical protein 0.0121416 0.363262 0.363262
Schistosoma mansoni hypothetical protein 0.0121416 0.363262 0.363262
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0121416 0.363262 0.363262
Toxoplasma gondii hypothetical protein 0.0121416 0.363262 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.00263827 0.0374353 0.103053
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0015464 0 0.5
Echinococcus granulosus carbonic anhydrase 0.0121416 0.363262 0.37728
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.00263827 0.0374353 0.0374353
Echinococcus multilocularis thioredoxin glutathione reductase 0.00761339 0.20801 0.216037
Schistosoma mansoni adapter molecule crk 0.00208196 0.0183621 0.0183621
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.002125 0.0198378 0.0206032
Plasmodium vivax thioredoxin reductase, putative 0.00761339 0.20801 1
Loa Loa (eye worm) hypothetical protein 0.0121416 0.363262 0.363262
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.00263827 0.0374353 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0121416 0.363262 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002125 0.0198378 0.0206032
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.00263827 0.0374353 0.0395312
Mycobacterium ulcerans flavoprotein disulfide reductase 0.00263827 0.0374353 0.0374353
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.00263827 0.0374353 0.179969
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.002125 0.0198378 0.0206032
Echinococcus multilocularis tyrosine protein kinase Fgr 0.002125 0.0198378 0.0206032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002125 0.0198378 0.0206032
Echinococcus granulosus tyrosine protein kinase Lyn 0.002125 0.0198378 0.0206032
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.00263827 0.0374353 0.0374353
Echinococcus granulosus carbonic anhydrase 0.0121416 0.363262 0.37728
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.002125 0.0198378 0.0206032
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0121416 0.363262 0.363262
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.00263827 0.0374353 0.0374353
Schistosoma mansoni carbonic anhydrase 0.0121416 0.363262 0.363262
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.00193798 0.0134258 0.0139439
Giardia lamblia NADH oxidase lateral transfer candidate 0.00263827 0.0374353 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0121416 0.363262 0.37728
Trypanosoma cruzi trypanothione reductase, putative 0.00263827 0.0374353 0.103053
Toxoplasma gondii NADPH-glutathione reductase 0.00263827 0.0374353 0.103053
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0121416 0.363262 0.363262
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.00263827 0.0374353 0.179969
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.00263827 0.0374353 0.0395312
Brugia malayi glutathione reductase 0.00761339 0.20801 0.216037
Schistosoma mansoni nck2/grb4 0.00208196 0.0183621 0.0183621
Plasmodium falciparum thioredoxin reductase 0.00761339 0.20801 0.572617
Loa Loa (eye worm) hypothetical protein 0.00208196 0.0183621 0.0183621
Plasmodium falciparum carbonic anhydrase 0.0121416 0.363262 1
Schistosoma mansoni growth factor receptor-bound protein 0.0296295 0.962846 0.962846
Trypanosoma brucei trypanothione reductase 0.00761339 0.20801 0.572617
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.00224668 0.0240095 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.002125 0.0198378 0.0206032
Trypanosoma cruzi trypanothione reductase, putative 0.00761339 0.20801 0.572617
Leishmania major trypanothione reductase 0.00761339 0.20801 0.572617
Brugia malayi Tyrosine-protein kinase abl-1 0.002125 0.0198378 0.0206032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.00263827 0.0374353 0.103053
Mycobacterium tuberculosis Probable oxidoreductase 0.00263827 0.0374353 0.0395312
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.00263827 0.0374353 0.103053
Echinococcus granulosus NCK adaptor protein 0.00208196 0.0183621 0.0190706
Brugia malayi Sex muscle abnormal protein 5 0.0296295 0.962846 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0015464 0 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.002125 0.0198378 0.0206032
Plasmodium falciparum thioredoxin reductase 0.00263827 0.0374353 0.103053
Echinococcus granulosus carbonic anhydrase II 0.0121416 0.363262 0.37728
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002125 0.0198378 0.0206032
Loa Loa (eye worm) hypothetical protein 0.0121416 0.363262 0.363262
Echinococcus multilocularis c src tyrosine kinase 0.002125 0.0198378 0.0206032
Schistosoma mansoni carbonic anhydrase-related 0.0121416 0.363262 0.363262
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0121416 0.363262 0.37728
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.00263827 0.0374353 0.103053
Echinococcus granulosus growth factor receptor bound protein 2 0.0296295 0.962846 1
Treponema pallidum NADH oxidase 0.00263827 0.0374353 0.5
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0121416 0.363262 0.37728
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0307132 1 1
Echinococcus multilocularis NCK adaptor protein 0.00208196 0.0183621 0.0190706
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.00263827 0.0374353 0.103053
Loa Loa (eye worm) SRC-1 0.002125 0.0198378 0.0198378
Schistosoma mansoni tyrosine kinase 0.002125 0.0198378 0.0198378
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0374353 0.103053
Brugia malayi Thioredoxin reductase 0.00761339 0.20801 0.216037
Echinococcus granulosus tyrosine protein kinase Fyn 0.002125 0.0198378 0.0206032
Brugia malayi SRC-1 0.002125 0.0198378 0.0206032
Loa Loa (eye worm) hypothetical protein 0.0307132 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.00208196 0.0183621 0.0183621
Echinococcus multilocularis carbonic anhydrase 0.0121416 0.363262 0.37728
Echinococcus multilocularis growth factor receptor bound protein 2 0.0296295 0.962846 1
Schistosoma mansoni tyrosine kinase 0.002125 0.0198378 0.0198378
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0291668 0.946981 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0296295 0.962846 0.962846
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00263827 0.0374353 0.5
Plasmodium vivax glutathione reductase, putative 0.00761339 0.20801 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.00263827 0.0374353 0.103053
Toxoplasma gondii thioredoxin reductase 0.00761339 0.20801 0.572617
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0121416 0.363262 0.37728
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0121416 0.363262 0.363262

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.12 uM Tested in vitro for trypanocidal activity against a drug sensitive strain of Trypanosoma brucei Lab 110 EATRO ChEMBL. 11206471
IC50 (functional) = 0.12 uM Tested in vitro for trypanocidal activity against a drug sensitive strain of Trypanosoma brucei Lab 110 EATRO ChEMBL. 11206471
IC50 (functional) = 0.14 uM Tested in vitro for trypanocidal activity against KETRI 243 an uncloned clinical isolate of Trypanosoma brucei. rhodesiense ChEMBL. 11206471
IC50 (functional) = 0.14 uM Tested in vitro for trypanocidal activity against KETRI 243 an uncloned clinical isolate of Trypanosoma brucei. rhodesiense ChEMBL. 11206471
IC50 (functional) = 0.15 uM Tested in vitro for trypanocidal activity against KETRI 243-As-10-3 a pentamidine and melarsoprol resistant clone of Trypanosoma brucei. rhodesiense KETRI 243 ChEMBL. 11206471
IC50 (functional) = 0.15 uM Tested in vitro for trypanocidal activity against KETRI 243-As-10-3 a pentamidine and melarsoprol resistant clone of Trypanosoma brucei. rhodesiense KETRI 243 ChEMBL. 11206471
IC50 (functional) = 0.16 uM Tested in vitro for trypanocidal activity against KETRI 269 an uncloned clinical isolate of Trypanosoma brucei. rhodesiense ChEMBL. 11206471
IC50 (functional) = 0.16 uM Tested in vitro for trypanocidal activity against KETRI 269 an uncloned clinical isolate of Trypanosoma brucei. rhodesiense ChEMBL. 11206471
IC50 (binding) = 8.4 uM Inhibition of [3H]MK-801 binding to rat NMDA receptor ChEMBL. 16563762
IC50 (binding) = 8.4 uM Inhibition of [3H]MK-801 binding to rat NMDA receptor ChEMBL. 16563762
Ki (binding) = 0.614 uM Tested for binding affinity against trypanothione reductase from Trypanosoma cruzi ChEMBL. 11206471
Ki (binding) = 0.614 uM Tested for binding affinity against trypanothione reductase from Trypanosoma cruzi ChEMBL. 11206471
Ratio IC50 (binding) = 1.49 Attenuation at rat NMDA receptor assessed as ratio of inhibition of [3H]MK-801 binding to NMDA receptor in presence to absence of spermine ChEMBL. 16563762
Ratio IC50 (binding) = 1.49 Attenuation at rat NMDA receptor assessed as ratio of inhibition of [3H]MK-801 binding to NMDA receptor in presence to absence of spermine ChEMBL. 16563762

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei ChEMBL23 11206471
Trypanosoma brucei gambiense 11206471

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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