Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1499 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1499 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1499 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1499 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0815 | 0.0046 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0812 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.1435 | 0.9081 | 0.9081 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1499 | 1 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1435 | 0.9081 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1499 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1499 | 1 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1435 | 0.9081 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1499 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1499 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0812 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1499 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1435 | 0.9081 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1499 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.