Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0749 | 0.0749 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3788 | 0.3537 |
Onchocerca volvulus | 0.0033 | 0.3788 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3788 | 0.3788 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3788 | 0.6076 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5718 | 0.5545 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0749 | 0.1201 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.6234 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3788 | 0.6076 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0749 | 0.1201 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6234 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3654 | 0.3654 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0749 | 0.1201 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6234 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.6234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3788 | 0.3788 |
Brugia malayi | hypothetical protein | 0.0043 | 0.6234 | 0.6081 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3788 | 0.6076 |
Schistosoma mansoni | lamin | 0.0033 | 0.3788 | 0.5541 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3788 | 0.5541 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0749 | 0.0375 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0749 | 0.1201 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.6234 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3788 | 0.3788 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0749 | 0.0749 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6234 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3788 | 0.6076 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0389 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5718 | 0.5718 |
Schistosoma mansoni | lamin | 0.0033 | 0.3788 | 0.5541 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0749 | 0.1201 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0749 | 0.0375 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3788 | 0.3537 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0749 | 0.1201 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3788 | 0.6076 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.6234 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.6234 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.3788 | 0.6076 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5718 | 0.906 |
Onchocerca volvulus | 0.0033 | 0.3788 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1000_uM (functional) | = 5.582 uM | PUBCHEM_BIOASSAY: In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504552] | ChEMBL. | No reference |
AbsAC35 (functional) | = 33.47 uM | PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
AbsAC35 (functional) | = 40.24 uM | PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3109 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (binding) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.