Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E receptor 1 (subtype EP1), 42kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin F receptor (FP) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 2 (subtype EP2), 53kDa | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin I2 (prostacyclin) receptor (IP) | Starlite/ChEMBL | References |
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 3 (subtype EP3) | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin E receptor 4 (subtype EP4) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.4963 | 0.6402 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.7751 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0163 | 0.4136 | 0.5336 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0228 | 0.7751 | 1 |
Mycobacterium ulcerans | hydrolase | 0.009 | 0 | 0.5 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0121 | 0.1755 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1755 | 0.2264 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.009 | 0 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0163 | 0.4136 | 1 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0121 | 0.1755 | 0.134 |
Brugia malayi | Hemopexin family protein | 0.0104 | 0.0827 | 0.1067 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0163 | 0.4136 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.009 | 0 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0178 | 0.4963 | 0.6402 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0228 | 0.7751 | 1 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0121 | 0.1755 | 0.134 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0268 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 66 nM | Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | = 66 nM | Binding affinity towards EP4 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP3 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards EP1 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards DP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards FP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards IP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Ki (binding) | > 13000 nM | Binding affinity towards TP receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs | ChEMBL. | 12643927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.