Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1553 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0605 | 0.3559 | 1 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0232 | 0.1027 | 0.5 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0218 | 0.093 | 0.0729 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1553 | 1 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0218 | 0.093 | 0.093 |
Brugia malayi | Presenilin family protein | 0.0232 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0232 | 0.1027 | 1 |
Echinococcus granulosus | presenilin | 0.0232 | 0.1027 | 0.0828 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0232 | 0.1027 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0232 | 0.1027 | 0.5 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0218 | 0.093 | 0.093 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0217 | 0.0217 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0232 | 0.1027 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0232 | 0.1027 | 0.0828 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0605 | 0.3559 | 1 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0218 | 0.093 | 0.0729 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0605 | 0.3559 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0217 | 0.0217 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0217 | 0.0217 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1553 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0081 | 0 | 0.5 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1553 | 1 | 1 |
Echinococcus multilocularis | presenilin | 0.0232 | 0.1027 | 0.0828 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.