Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli O157:H7 | Shiga toxin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | imidazolonepropionase | Shiga toxin | 89 aa | 94 aa | 26.6 % |
Schistosoma mansoni | katanin P80 subunit | Shiga toxin | 89 aa | 72 aa | 23.6 % |
Schistosoma japonicum | Katanin p80 WD40-containing subunit B1, putative | Shiga toxin | 89 aa | 72 aa | 23.6 % |
Trichomonas vaginalis | coatomer beta subunit, putative | Shiga toxin | 89 aa | 87 aa | 27.6 % |
Echinococcus granulosus | imidazolonepropionase | Shiga toxin | 89 aa | 94 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0234 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0234 | 0 | 0.5 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 1 | 1 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0238 | 1 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0234 | 0 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0234 | 0 | 0.5 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0238 | 1 | 1 |
Echinococcus multilocularis | thymidine kinase | 0.0238 | 1 | 1 |
Echinococcus granulosus | thymidine kinase | 0.0238 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0234 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0234 | 0 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0234 | 0 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0234 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0234 | 0 | 0.5 |
Schistosoma mansoni | thymidine kinase | 0.0238 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5648 um | PUBCHEM_BIOASSAY: A qHTS for Small Molecule Inhibitors of Shiga Toxin (Confirmatory). (Class of assay: confirmatory) [Related pubchem assays: 2314, 2318, 2315 ] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.