Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | corticotropin releasing hormone binding protein | No references | |
Homo sapiens | corticotropin releasing hormone receptor 2 | No references | |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 2 | 438 aa | 383 aa | 26.1 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0047 | 0.0255 | 0.0464 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0124 | 0.3484 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0098 | 0.0282 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.5884 | 0.8517 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0805 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3484 | 0.4036 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0124 | 0.3484 | 1 |
Onchocerca volvulus | 0.0182 | 0.5972 | 1 | |
Onchocerca volvulus | Protein Malvolio homolog | 0.0124 | 0.3484 | 0.5763 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0114 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0098 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0595 | 0.069 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0098 | 0.0114 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0114 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.6892 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5884 | 0.6818 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.8631 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0098 | 0.0114 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.5884 | 0.8517 |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0124 | 0.3484 | 0.4983 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0805 | 0.0933 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0124 | 0.3484 | 0.4983 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.5972 | 0.692 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0595 | 0.1709 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0114 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0595 | 0.0731 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0595 | 0.0731 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0098 | 0.5 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0098 | 0.0114 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.6892 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0595 | 0.0731 |
Plasmodium vivax | metal transporter, putative | 0.0124 | 0.3484 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0595 | 0.1709 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0098 | 0.0114 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0098 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0595 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.3484 | 0.4036 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0076 | 0.1489 | 0.1405 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.5884 | 0.6818 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0098 | 0.0114 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0595 | 0.0731 |
Brugia malayi | hypothetical protein | 0.0182 | 0.5972 | 0.692 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.5884 | 0.6818 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0098 | 0.5 |
Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0047 | 0.0255 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0114 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0098 | 0.0114 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0098 | 0.0282 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0098 | 0.5 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0124 | 0.3484 | 1 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0124 | 0.3484 | 0.4036 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0098 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.5884 | 0.8517 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0595 | 0.1709 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.8631 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0098 | 0.0114 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0124 | 0.3484 | 1 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0076 | 0.1489 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0098 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0124 | 0.3484 | 0.5 |
Mycobacterium leprae | possible membrane transport protein | 0.0047 | 0.0255 | 0.113 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0098 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 53 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 2.09 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.