Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0446 | 0.8435 | 1 |
Onchocerca volvulus | 0.0505 | 1 | 1 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0505 | 1 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0446 | 0.8435 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0299 | 0.4567 | 0.5414 |
Brugia malayi | Cytochrome P450 family protein | 0.0299 | 0.4567 | 0.5414 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0446 | 0.8435 | 0.8435 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.7966 | 0.9445 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0446 | 0.8435 | 0.8435 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0446 | 0.8435 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0428 | 0.7966 | 0.9445 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0446 | 0.8435 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0505 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0126 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0505 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0428 | 0.7966 | 0.9445 |
Onchocerca volvulus | 0.0505 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (binding) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.