TDR Targets

Basic information

Technical information

TDR Targets ID: 1392001
Name: 705941-45-3
MW: 186.208 | Formula: C8H14N2O3
H donors: 1 H acceptors: 3 LogP: -3.15 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CN1CCN(CC1)C(=O)C
InChi: 1S/C8H14N2O3/c1-7(11)10-4-2-9(3-5-10)6-8(12)13/h2-6H2,1H3,(H,12,13)
InChiKey: LOJWUWGLJZYAOE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ST5213232
(4-Acetyl-piperazin-1-yl)-acetic acid
MLS000685987
SMR000324857
ZINC02456625

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.9248	0.9248
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0164	0.2416
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0012	0.0164	0.2416
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0038	0.0678	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0004	0	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0678	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus granulosus	multidrug resistance protein 1	0.0008	0.0092	0.1355
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0012	0.0164	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0164	0.0164
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0038	0.0678	1
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0507	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0164	0.2416
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0038	0.0678	1
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0004	0	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0004	0	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0004	0	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0678	1
Trichomonas vaginalis	taga, putative	0.0012	0.0164	0.2416
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0038	0.0678	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0164	0.2416
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0004	0	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	abcb9, putative	0.0012	0.0164	0.2416
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0038	0.0678	0.0678
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0038	0.0678	1
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0164	0.2416
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0004	0	0.5
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0038	0.0678	1
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.0507	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.9248	0.9248
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0012	0.0164	0.2416
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Brugia malayi	ABC transporter family protein	0.0012	0.0164	0.0164
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0678	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0038	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Echinococcus granulosus	multidrug resistance protein 1	0.0008	0.0092	0.1355
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Giardia lamblia	hypothetical protein	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.047	0.9248	0.9248
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Schistosoma mansoni	smdr2	0.0012	0.0164	0.0164
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0038	0.0678	1
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0038	0.0678	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0164	0.2416
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0038	0.0678	1
Entamoeba histolytica	P-glycoprotein-2	0.0012	0.0164	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0038	0.0678	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0507	1	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0012	0.0164	0.5
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0038	0.0678	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0678	0.0678
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0038	0.0678	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0164	0.2416
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0164	0.2416
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0678	0.0678
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Brugia malayi	multidrug resistance protein 3	0.0012	0.0164	0.0164
Entamoeba histolytica	P-glycoprotein-2, putative	0.0012	0.0164	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0164	0.0164
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0038	0.0678	1
Entamoeba histolytica	P-glycoprotein-1	0.0012	0.0164	1
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0038	0.0678	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0008	0.0092	0.1355
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0164	0.0164
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0164	0.2416
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Plasmodium falciparum	phosphodiesterase delta, putative	0.0038	0.0678	1
Plasmodium falciparum	multidrug resistance protein 1	0.0012	0.0164	0.2416
Leishmania major	hypothetical protein, conserved	0.0038	0.0678	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0164	0.2416
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0012	0.0161	0.2378
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0038	0.0678	0.0678
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0038	0.0678	0.0678
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0012	0.0161	0.2378
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0164	0.0164
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0038	0.0678	1
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0038	0.0678	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0164	0.2416
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0038	0.0678	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0038	0.0678	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0164	0.2416
Onchocerca volvulus		0.0012	0.0164	0.5
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0164	0.2416
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0678	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0164	0.2416
Entamoeba histolytica	P-glycoprotein-5	0.0012	0.0164	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0012	0.0164	0.0164
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Entamoeba histolytica	P-glycoprotein 5, putative	0.0012	0.0164	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0038	0.0678	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0038	0.0678	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0678	1
Trichomonas vaginalis	abcb9, putative	0.0012	0.0164	0.2416
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0038	0.0678	0.0678
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	abcb9, putative	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0038	0.0678	1
Entamoeba histolytica	P-glyco protein 6, putative	0.0012	0.0164	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0678	0.0678
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0038	0.0678	0.0678
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0164	0.2416
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0038	0.0678	1
Entamoeba histolytica	P-glycoprotein-2	0.0012	0.0164	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0164	0.2416
Plasmodium vivax	multidrug resistance protein 1, putative	0.0012	0.0164	0.2416
Giardia lamblia	Hypothetical protein	0.0038	0.0678	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0038	0.0678	0.0678
Plasmodium vivax	phosphodiesterase gamma, putative	0.0038	0.0678	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0008	0.0092	0.1355
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0164	0.2416
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0038	0.0678	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0164	0.2416
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0678	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0678	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0678	1
Leishmania major	p-glycoprotein	0.0012	0.0164	0.2416
Leishmania major	hypothetical protein, conserved	0.0038	0.0678	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0161	0.0161
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0164	0.2416
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0038	0.0678	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0038	0.0678	0.0678
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0004	0	0.5
Loa Loa (eye worm)	multidrug resistance protein 3	0.0012	0.0164	0.0164
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0004	0	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416
Loa Loa (eye worm)	PDE1B protein	0.0038	0.0678	0.0678
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0678	1
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0004	0	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0164	0.2416
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0678	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0038	0.0678	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0164	0.2416
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0038	0.0678	1
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0038	0.0678	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0164	0.2416

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1525302

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1392001