Detailed information for compound 1393678

Basic information

Technical information
  • TDR Targets ID: 1393678
  • Name: N-ethyl-N-(2-ethylphenyl)-4H-thieno[4,5-c]thi ochromene-2-carboxamide
  • MW: 379.538 | Formula: C22H21NOS2
  • H donors: 0 H acceptors: 1 LogP: 5.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1N(C(=O)c1sc2c(c1)CSc1c2cccc1)CC
  • InChi: 1S/C22H21NOS2/c1-3-15-9-5-7-11-18(15)23(4-2)22(24)20-13-16-14-25-19-12-8-6-10-17(19)21(16)26-20/h5-13H,3-4,14H2,1-2H3
  • InChiKey: BHEUVOOENAQKIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • C849-0973
  • NCGC00113684-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0523 0.5
Loa Loa (eye worm) hypothetical protein 0.019 0.0523 0.0523
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0138 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0138 0.5
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.2548 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0523 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Loa Loa (eye worm) hypothetical protein 0.2358 0.9235 0.9235
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0138 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.019 0.0523 0.371
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.019 0.0523 0.0391
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0007 0.5
Plasmodium vivax phosphodiesterase gamma, putative 0.019 0.0523 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.019 0.0523 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 1
Giardia lamblia hypothetical protein 0.019 0.0523 0.5
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.019 0.0523 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Plasmodium falciparum phosphodiesterase delta, putative 0.019 0.0523 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.019 0.0523 0.371
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Loa Loa (eye worm) hypothetical protein 0.2358 0.9235 0.9235
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0523 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.019 0.0523 0.5
Giardia lamblia Hypothetical protein 0.019 0.0523 0.5
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.019 0.0523 0.5
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.2548 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.019 0.0523 0.0523
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus multilocularis tumor protein p63 0.0408 0.1398 1
Loa Loa (eye worm) hypothetical protein 0.2548 1 1
Loa Loa (eye worm) hypothetical protein 0.2358 0.9235 0.9235
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.019 0.0523 0.5
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.019 0.0523 0.0391
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0138 0.5
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.019 0.0523 0.371
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.019 0.0523 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.019 0.0523 0.371
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0007 0.5
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.019 0.0523 0.0523
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0523 0.5
Loa Loa (eye worm) hypothetical protein 0.019 0.0523 0.0523
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.019 0.0523 0.371
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Leishmania major hypothetical protein, conserved 0.019 0.0523 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0138 0.5
Brugia malayi Probable ClpP-like protease 0.0094 0.0138 0.0138
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.019 0.0523 0.371
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.019 0.0523 0.371
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0138 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0523 0.5
Trichomonas vaginalis conserved hypothetical protein 0.019 0.0523 0.5
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.019 0.0523 0.371
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0523 0.5
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Plasmodium falciparum phosphodiesterase gamma, putative 0.019 0.0523 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.019 0.0523 0.371
Plasmodium falciparum cGMP-specific phosphodiesterase 0.019 0.0523 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.019 0.0523 0.0391
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.019 0.0523 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.019 0.0523 0.0523
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0138 0.094
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.019 0.0523 0.371
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.019 0.0523 0.0523
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.019 0.0523 0.371
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.019 0.0523 0.371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Leishmania major hypothetical protein, conserved 0.019 0.0523 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.019 0.0523 0.371
Loa Loa (eye worm) hypothetical protein 0.0094 0.0138 0.0138
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.019 0.0523 0.5
Loa Loa (eye worm) PDE1B protein 0.019 0.0523 0.0523
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.019 0.0523 0.5
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.019 0.0523 0.371
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.019 0.0523 0.5
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus granulosus tumor protein p63 0.0408 0.1398 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.019 0.0523 0.371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.019 0.0523 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0138 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.019 0.0523 0.5
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.019 0.0523 0.371
Loa Loa (eye worm) hypothetical protein 0.019 0.0523 0.0523
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.019 0.0523 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.019 0.0523 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.019 0.0523 0.5
Trypanosoma brucei hypothetical protein, conserved 0.019 0.0523 0.5
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.019 0.0523 0.0523
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0138 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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