Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0205 | 0.8073 | 0.8073 |
Echinococcus granulosus | disintegrin and metalloproteinase | 0.019 | 0.707 | 0.707 |
Schistosoma mansoni | dihydroceramide desaturase | 0.019 | 0.707 | 0.8758 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8073 | 0.8073 |
Loa Loa (eye worm) | matrixin family protein | 0.0154 | 0.4509 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0141 | 0.3607 | 0.5354 |
Loa Loa (eye worm) | disintegrin family protein | 0.0139 | 0.3404 | 0.4306 |
Brugia malayi | Disintegrin family protein | 0.019 | 0.707 | 1 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0093 | 0.0206 | 0.0256 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0127 | 0.2568 | 0.2568 |
Echinococcus multilocularis | disintegrin and metalloproteinase | 0.019 | 0.707 | 0.707 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0127 | 0.2568 | 0.2568 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8073 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0141 | 0.3607 | 1 |
Brugia malayi | Matrixin family protein | 0.0154 | 0.4509 | 0.6377 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0232 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0141 | 0.3607 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8073 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.