Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0068 | 0.0097 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0014 | 0.5 |
Onchocerca volvulus | 0.0248 | 0.2661 | 0.4736 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0249 | 0.0673 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0486 | 0.1354 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0157 | 0.1557 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0249 | 0.0673 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0316 | 0.3502 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0157 | 0.1557 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.0486 | 0.0845 |
Brugia malayi | hypothetical protein | 0.0488 | 0.5602 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0316 | 0.3502 | 0.6241 |
Schistosoma mansoni | lozenge | 0.0061 | 0.0381 | 0.1053 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.027 | 0.0458 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.0486 | 0.0845 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0316 | 0.3502 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.0486 | 0.0845 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0486 | 0.1354 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0157 | 0.1557 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0486 | 0.1354 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0249 | 0.0673 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.5602 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.2293 | 0.4079 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.0486 | 0.0845 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0118 | 0.1071 | 0.3031 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.027 | 0.0458 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0068 | 0.0097 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0486 | 0.1354 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.2293 | 0.4079 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0249 | 0.0711 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0068 | 0.0155 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.027 | 0.0458 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0316 | 0.3502 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.0486 | 0.0473 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0249 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.027 | 0.0458 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0249 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 0.5602 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0322 | 0.3572 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0249 | 0.0711 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0014 | 0.004 |
Brugia malayi | RNA binding protein | 0.007 | 0.0486 | 0.0845 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0118 | 0.1071 | 0.3031 |
Leishmania major | 0.0316 | 0.3502 | 0.5 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0316 | 0.3502 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0249 | 0.042 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0316 | 0.3502 | 0.6241 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.0486 | 0.1388 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Brugia malayi | TAR-binding protein | 0.007 | 0.0486 | 0.0845 |
Loa Loa (eye worm) | runx1 | 0.0061 | 0.0381 | 0.0657 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0322 | 0.3572 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0486 | 0.1354 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0249 | 0.0235 |
Echinococcus multilocularis | Protein lozenge | 0.0061 | 0.0381 | 0.0368 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0316 | 0.3502 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0322 | 0.3572 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0316 | 0.3502 | 0.3492 |
Onchocerca volvulus | 0.0488 | 0.5602 | 1 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0316 | 0.3502 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.