Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | Starlite/ChEMBL | References |
Homo sapiens | folate receptor 1 (adult) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0124 | 0.1953 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.018 | 0.3144 | 1 |
Onchocerca volvulus | 0.004 | 0.0171 | 1 | |
Echinococcus multilocularis | folate receptor beta | 0.0503 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.004 | 0.0171 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.018 | 0.3144 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.018 | 0.3144 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Hx shift (functional) | > 49 | Tested for Hypoxanthine (Hx) shift. | ChEMBL. | 9258357 |
IC50 (functional) | = 0.031 uM | Tested for cell growth inhibition against L1210 murine leukemia. | ChEMBL. | 9258357 |
IC50 (functional) | = 0.031 uM | Tested for cell growth inhibition against L1210 murine leukemia. | ChEMBL. | 9258357 |
IC50 (functional) | = 0.032 uM | Tested for cell growth inhibition against CCRF-CEM a human lymphoblastic leukemia line of T-cell origin. | ChEMBL. | 9258357 |
IC50 (functional) | = 0.032 uM | Tested for cell growth inhibition against CCRF-CEM a human lymphoblastic leukemia line of T-cell origin. | ChEMBL. | 9258357 |
IC50 (functional) | = 18 uM | Tested for cell growth inhibition against L1210/CI920 cell line. | ChEMBL. | 9258357 |
IC50 (functional) | = 18 uM | Tested for cell growth inhibition against L1210/CI920 cell line. | ChEMBL. | 9258357 |
Kd (binding) | = 0.153 nM | compound was tested for the ability to function as transport substrates for the human folate-binding protein(mFBP) | ChEMBL. | 9258357 |
Kd (binding) | = 0.153 nM | compound was tested for the ability to function as transport substrates for the human folate-binding protein(mFBP) | ChEMBL. | 9258357 |
Ki (binding) | = 0.035 uM | Inhibition of recombinant human Glycinamide Ribonucleotide Transformylase (GART) using N10-formyl-5,8-dideazafolate (FDDF) as the cofactor . | ChEMBL. | 9258357 |
Ki (binding) | = 0.035 uM | Inhibition of recombinant human Glycinamide Ribonucleotide Transformylase (GART) using N10-formyl-5,8-dideazafolate (FDDF) as the cofactor . | ChEMBL. | 9258357 |
Vm/Km (binding) | = 0.371 | compound was tested for inhibition against Folyl-polyglutamate synthase (FPGS) of rat liver. | ChEMBL. | 9258357 |
Vm/Km (binding) | = 0.371 | compound was tested for inhibition against Folyl-polyglutamate synthase (FPGS) of rat liver. | ChEMBL. | 9258357 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9258357 | |
Mus musculus | ChEMBL23 | 9258357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.