Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0388 | 0.3841 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0388 | 0.3841 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0388 | 0.3841 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0388 | 0.3841 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0112 | 0.0616 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0148 | 0.1339 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0148 | 0.1339 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0112 | 0.0616 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0112 | 0.0616 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0032 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0032 | 0.2837 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0032 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0148 | 0.1339 | 1 |
Chlamydia trachomatis | peptide deformylase | 0.0388 | 0.3841 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0112 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0388 | 0.3841 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0112 | 0.0211 |
Mycobacterium ulcerans | peptide deformylase | 0.0388 | 0.3841 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0148 | 0.1339 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0032 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0032 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0388 | 0.3841 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0032 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0148 | 0.1339 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0032 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0388 | 0.3841 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0112 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0112 | 0.0211 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0112 | 0.0211 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0148 | 0.1339 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0112 | 0.0211 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0112 | 0.0616 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0148 | 0.1339 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0158 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.